Distinct roles of Toll-like receptor-4 expression in neonate infected by neonatal meningitis

American Journal of BioMedicine  Volume 2, Issue 8, pages 1038-1049 September 2014

Jack B. Smith; Enza Hijiya; Kimberly Kumar; David Uleri; Armond Gresnigt


The objective of the study is to evaluate the expression of Toll-like receptor-4 (TLR-4) in neonate infected by neonatal meningitis. Thirty neonate under the age 30 days with the clinical suspicion of neonatal meningitis were enrolled in the study. CSF and Nasopharyngeal secretions were obtained for laboratory testing, and blood samples were obtained for flow cytometry and cytokine level analysis. The mean fluorescence index, used as a measure of TLR-4 expression by monocytes, was significantly higher with neonatal meningitis than in the control group neonate (51.26 ± 29.41 vs. 28.22 ± 12, respectively; P= 0.002). We concluded that TL4 expression by monocytes are higher in neonate with positive PCR results for neonatal meningitis.

Keywords: Neonatal meningitis; TLR-4; CSF; Cytokine


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