Helicobacter pylori and IL-23R gene polymorphism role in degeneration of gastric mucosa


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Farid Zandi1, Hedayatollah Shirzad2, Nader Bagheri2, Afshin Taghikhani3, GhorbanaliRahimian3, Mohammad Hossein Sanei4, Fateme Azadegan5, Siva zandi6, Behnam Zamanzad2*
Author Affiliations
∗Correspondence author e-mail: behnamzamanzad5@gmail.com: 1Department of Immunology and Microbiology, Kurdistan University of Medical Sciences, Sanandaj, Iran.2Department of Immunology and Microbiology, Shahrekord University of Medical Sciences, Shahrekord, Iran. 3Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran. 4Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 5Cellular & Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran 6Cellular & Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran

 

Abstract

Relationship between H.pylori (Hp) colonizes and gastric inflammation is widely accepted. Polymorphisms in inflammation related genes such as cytokines and their receptors were thought to partly determine the outcome of Hp infection. Interleukin 23 receptor (IL23R) may relate to degeneration of gastric mucosa. We evaluate association of IL23R +2199 rs10889677 polymorphism and grade of Hp infection with degeneration of gastric mucosa and grade of Hp infection. Biopsies taken from the corpus patients were classified as Hp-infected and Hp-uninfected. The histological severity of Hp infection and degeneration of gastric mucosa were graded from normal to severe. Polymorphism in IL23R was evaluated by PCR-RFLP. AC genotype was related to mild degeneration in Hp-infected subjects (P=0.017). Mild and moderate grades of Hp infection were found related to mild grade of
gastric mucosal degeneration (P=0.004 for mild and P=0.037 for moderate grade), sever grade was associated with non-degeneration (P=0.010). We didn’t found any association between IL-23R +2199 polymorphism and grades of Hp infection (P>0.05). We concluded that AC genotype of IL-23R polymorphism influences degeneration of gastric mucosa according to presence of Hp and grades of Hp infection.

Key words: Degeneration; IL-23R; Polymorphism; Helicobacter pylori; Mucosa

Copyright © 2014 by The American Society for BioMedicine and BM-Publisher, Inc.

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DOI: http://dx.doi.org/10.18081/2333-5106/014-03/176-188
American Journal of BioMedicine 2014, Volume 2, Issue 3, pages 176-188
Received April 30, 2014; Accepted June 28, 2014, Published August 22, 2014

How to cite this article
Zandi F, Shirzad H, Bagheri N, et al. Helicobacter pylori and IL-23R gene polymorphism role in degeneration of gastric mucosa. American Journal of BioMedicine 2014;2(3):176-188.

Case report outline
1. Abstract
2. Keywords
3. Introduction
4. Methods
5. Results
6. Discussion
7. References

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