Infective endocarditis in Marfan syndrome patient unresponsive to usual therapy

doi: 10.18081/ajbm/2333-5106/015-04/164-170
American Journal of BioMedicine Volume 3, Issue 4, pages 164-170
Published: 11 April 2015

David  Shwann


A 25-year-oldman with Marfan syndrome and mitral valve regurgitation been healthy without other risk factors for infective endocarditis, presented with 8 days of fever, chest pain and cough. She had presented to his doctor in private clinic 13 days earlier and was prescribed antibiotics [Amoxilline 500 mg/8hrs] for a suspected respiratory tract infection. Despite this therapy, his condition progress worse and developed a fulminant rash, prompting emergent admission for further evaluation.

Keywords: Marfan syndrom; Infective endocarditis; Mitral valve regurgitation

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1. Bolar N, Van Laer L, Loeys BL. Marfan syndrome: from gene to therapy. Curr Opin Pediatr 2012; 24(4):498-504. [PubMed]

2. Lee B, Godfrey M, Vitale E, et al. Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes. Nature 1991; 352:337-339.

3. Loeys BL, Dietz HC, Braverman AC, et al. The revised Ghent nosology for the Marfan syndrome. J Med Genet 2010; 47(7):476-85. [PubMed]

4. Van de Velde S, Fillman R, Yandow S. Protrusio acetabuli in Marfan syndrome. History, diagnosis, and treatment. J Bone Joint Surg Am 2006; 88(3):639-46. [PubMed]

5. Weigang E, Ghanem N, Chang XC, et al. Evaluation of three different measurement methods for dural ectasia in Marfan syndrome. Clin Radiol 2006; 61(11):971-8. [PubMed]

6. Epaulard O, Roch N, Potton L, Pavese P, Brion JP, Stahl JP. Infective endocarditis-related stroke: diagnostic delay and prognostic factors. Scand J Infect Dis 2009; 41(8):558-62. [PubMed]

7. Durack DT, Lukes AS, Bright DK. New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service. Am J Med 1994; 96(3):200-9. [PubMed]

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