Up-regulation of interleukin-33 serum levels in metastatic prostate cancer

American Journal of BioMedicine  Volume 2, Issue 8, pages 928-939, August 2014

Xiaoli Zheng; Jin Chu; Hong Jing; Le Choi; Min Wang; Wei Zhou


Prostate cancer is one of the most frequent cancers worldwide. IL-33 is the most recently described member of the IL-1 family of cytokines and is a ligand for the ST2 receptor. IL-33 is expressed intracellularly predominantly by stromal cells such as endothelial and epithelial cells as well as smooth muscle cells and fibroblasts and it is involved in the pathogenesis of different inflammatory process. The present study was undertaken to evaluate the prognostic significance of the serum levels IL-33 in patients with prostate cancer Ninety-five patients with prostate cancer, ages 59–88 years (71.2 ± 0.34 years), were examined in the present study, the exclusion criteria were presence of autoimmune diseases and none were under any treatment for prostate cancer at the time of examination. The diagnosis of prostate cancer was confirmed by needle biopsy or by C. Blood for the measurement of serum IL-33 was collected into nonheparinized tubes. Prognostic significance of tumor on disease-specific survival was assessed using univariate and multivariate Cox’s proportional hazards model analyses. Serum IL-33 levels were significantly higher in patients with metastatic prostate cancer than in patients with stage B and stage C prostate cancer, and univariate analysis demonstrated that IL-33 was associated with a poor prognosis in metastatic prostate cancer patients. These results indicate that the serum IL-33 level may be associated with the prognosis of patients with prostate cancer.

Keywords: IL-33; Prostate cancer; Autoimmune diseases; Univariate and multivariate Cox’s proportional hazards model analyses

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