Regorafenib in combination with 5-FU versus bevacizumab in advance relapsed colorectal cancer

Research Article
American Journal of BioMedicine Volume 3, Issue 11, pages 699-711
Received: June 11, 2015; accepted: October 01, 2015; published: November 11, 2015

Thompson Wintera, Paul Bodnara, b, Dong-Chan Caoa, c, Charles Patela, Mechelle Dulskasa, Guang Lianga, d mail of corresponding author


Colorectal cancer remains one of the most deadly cancers in the U.S., researchers are making steady progress against this disease. New drugs allow people with even the most advanced metastatic disease tolive longer. We did a systematic review and meta-analysis to assess response to and survival after Regorafenib treatment in patients with advance relapsed colorectal carcer. We searched MEDLINE, Embase, Ovid, and Cochrane Central databases for published studies, and we used and other websites to find unpublished studies and conference abstracts. We included prospective and retrospective studies in which Regorafenib versus bevacizumab were administered to patients. Data were extracted independently by two investigators based on strict selection criteria. A random-effects model was used to pool outcomes across studies because of anticipated heterogeneity. Our primary outcome was increased survival from the first infusion of Regorafenib versus bevacizumab. Randomised clinical trials are needed urgently to assess different treatment modalities for advance relapsed colorectal carcer.

Keywords: Colorectal cancer; Regorafenib; Bevacizumab; Meta-analysis; VEGF

Copyright © 2015 by The American Society for BioMedicine and BM-Publisher, Inc.



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