The relative effect of hypertension on stroke risk in women compared with men: random-effects meta-analysis

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American Journal of BioMedicine  Volume 2, Issue 6, pages 665-674, June 2014

Hua Lee; Tong Sun; Mao Zhou; Yong Liu


It is well established that hypertension is the main risk factor for stroke and can cause stroke through many mechanisms. Many studies have been reported on whether the association between increments in blood pressure and cardiovascular disease differs between men and women. We performed a systematic review and meta-analysis to estimate the relative effect of hypertension on stroke risk in women compared with men. We systematically searched PubMed, google scholar and Scopus for reports of prospective, population-based cohort studies published between April 1, 2003, and Februery1, 2014. Studies were selected if they reported male: female estimates of the relative risk for stroke associated with hypertension and the data obtained through using random-effects meta-analysis. The data included 102 prospective cohort studies, representing 81061 individuals (41% women) and 1913 fatal and non-fatal strokes were involved in random-effects meta-analysis. Overall, women with hypertension had a greater risk of stroke [Relative risk=1·33 (1·19-1·89; I5=0%)].

Keywords: Stroke; Hypertension; Cohort study; Meta-analysis; female


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