Progress on the Pivotal Role and Application of Exosomes in Hodgkin Lymphoma: Carcinogenesis, Diagnosis, Therapy, and Prognosis

Research Article

American Journal of BioMedicine

Volume 12, Issue 3, 2024, Pages 101- 116 10.18081/2333-5106/2024.12/101

Xinxin Zhao, Jing Hu, Winnie Chen, Huali Feng ^1*

¹Department of Hematology, Medical College, Qinghai University, China.

Received 11 June 2024; revised 03 August 2024; accepted 31 August 2024; published 20 September 2024

Abstract

Hodgkin lymphoma (HL), also known as Hodgkin’s disease (HD), is a type of cancer that originates in the lymphatic system. It is divided into two main types: classical HL and nodular lymphocyte-predominant HL. The current challenges encountered in the pivotal role and application of exosomes in Hodgkin lymphoma, future perspectives and emerging technologies as novel strategies include: the combined detection of ctDNA and exosomal proteins and bioinformatics for the minimally invasive diagnosis and monitoring of tumor recurrence and treatment response within Hodgkin lymphoma; the use of exosomes to interfere with or regulate various cytokines, microRNAs, BTLAs, CEACAMs, latent membrane protein-1, multidrug resistance proteins, and heparanase as potential molecular therapy targets, together with drug therapy, microbial therapy, gene therapy, anti-tumor therapy, immunizing therapy, immune checkpoint inhibitors, and chimeric antigen receptor T-cell therapy to avoid resistance, enhance therapeutic effects, promote immunity, and improve the prognosis of relapsed or refractory Hodgkin lymphoma; the use of radiolabeled antibodies, exosomal imaging, and radiotherapy to establish a 'lock-key' therapy as a reference for targeted therapy efficiencies in various stages, and the use of vaccine or immune random libraries, exosome biotechnology strategies, such as dendritic cell vaccine therapy or exosome natural or artificial cargo carrying and delivery, as potential alternatives in the combined immunization therapy of Hodgkin lymphoma. We believe that the diversity and development of exosomes will promote comprehensive applications that can have a potential therapeutic impact on clinical research in Hodgkin lymphoma.

Keywords: Hodgkin lymphoma; Exosomes; Pivotal Role; microRNAs

Copyright © 2024 Feng, et al. This article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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APA

Zhao X, Hu J, Chen W, Feng H.(2024, September 20). Progress on the Pivotal Role and Application of Exosomes in Hodgkin Lymphoma: Carcinogenesis, Diagnosis, Therapy, and Prognosis. Retrieved September 20, 2024, from Ajbm.net website: https://ajbm.net/research-article_122624html/

MLA

Xinxin Zhao, Jing Hu, Winnie Chen, Huali Feng “Progress on the Pivotal Role and Application of Exosomes in Hodgkin Lymphoma: Carcinogenesis, Diagnosis, Therapy, and Prognosis.” Ajbm.net, September 20. 2024, https://ajbm.net/research-article_122624html/.

HARVARD

Xinxin Zhao, Jing Hu, Winnie Chen, Huali Feng. (2024) Progress on the Pivotal Role and Application of Exosomes in Hodgkin Lymphoma: Carcinogenesis, Diagnosis, Therapy, and Prognosis, Ajbm.net. Available at: https://ajbm.net/research-article_122624html/ (Accessed: September 20, 2024).

VANCOUVER

Xinxin Zhao, Jing Hu, Winnie Chen, Huali Feng. Progress on the Pivotal Role and Application of Exosomes in Hodgkin Lymphoma: Carcinogenesis, Diagnosis, Therapy, and Prognosis [Internet]. Ajbm.net. 2024 [cited 2024 September 20]. Available from: https://ajbm.net/research-article_122624html/

Progress on the Pivotal Role and Application of Exosomes in Hodgkin Lymphoma: Carcinogenesis, Diagnosis, Therapy, and Prognosis

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