Therapeutic use of autologous hematopoietic bone marrow transplant combined with concentrated platelet in infected surgical wounds: single-center prospective study

Research Article

American Journal of BioMedicine

Volume 12, Issue 2, 2024, Pages 52-51 10.18081/2333-5106/2024.12/52

Nasser Ghaly Yousif ¹ *, Bhat B ², Hani G. Yousif ³, Guda EN ²

¹Department of Medicine, Medical School, University of AlMuthanna, Iraq. ²Department of Public Health and Mortality Studies, Mumbai India . ³ Al-furat Al-awsat Technical University

Received 22 December 2023; revised 02 April 2024; accepted 15 April 2024; published 02 May 2024

Abstract

The healing wound is the consecutive process of maintaining tissue integrity including inflammatory, proliferative, and remodeling processes. Stem cells can self-renew, and also to differentiate into all cell types, and are involved in physiological regeneration, use of mesenchymal stem cells deriving from the bone marrow with PRP has potentiated the healing process. We conducted a single-arm pilot prospective analytical study was performed on 15 patients whose mean age was 31 years (range: 29–51 years), with refractory abdominal wounds at a private hospital in Iraq from March 30, 2022, to March 2023. Ten days after the stem cell transplant the re-enforcement with PRP subcutaneous injection around wounds. Small papules of granulation tissue appeared over the wound, and tissue granulation increased from 80% (30.26–80.00%) to 100% (81–100%). At the same time, the wound size was reduced by 60% (52.10–78.23%). The follow-up period was 7–24 months, during which no recurrence of the wound was found. In conclusion, the current study is the first to characterize the safety and efficacy of bone marrow-derived stem cells in combination with PRP in the treatment of refractory abdominal wound infection. All patients achieved a 100% healing rate in a short time, and no treatment-related adverse reactions occurred during the treatment.

Keywords: Bone marrow; Stem cells; PRP; Wound infections

Copyright © 2024 Yousif, et al. This article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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APA

Yousif NG, Bhat B, Yousif HG, Guda EN.(2024, May 02).Therapeutic use of autologous hematopoietic bone marrow transplant combined with concentrated platelet in infected surgical wounds: single-center prospective study. Retrieved May 02, 2024, from Ajbm.net website: https://ajbm.net/research-article_122620html/

MLA

Nasser Ghaly Yousif, Bhat B, Hani G. Yousif, Guda EN “Therapeutic use of autologous hematopoietic bone marrow transplant combined with concentrated platelet in infected surgical wounds: single-center prospective study.” Ajbm.net, 02 May. 2024, https://ajbm.net/research-article_122620html/.

HARVARD

Nasser Ghaly Yousif, Bhat B, Hani G. Yousif, Guda EN. (2024) Therapeutic use of autologous hematopoietic bone marrow transplant combined with concentrated platelet in infected surgical wounds: single-center prospective study, Ajbm.net. Available at: https://ajbm.net/research-article_122620html/ (Accessed: May 102, 2024).

VANCOUVER

Nasser Ghaly Yousif, Bhat B, Hani G. Yousif, Guda EN. Therapeutic use of autologous hematopoietic bone marrow transplant combined with concentrated platelet in infected surgical wounds: single-center prospective study [Internet]. Ajbm.net. 2024 [cited 2024 May 02]. Available from: https://ajbm.net/research-article_122620html/

Therapeutic use of autologous hematopoietic bone marrow transplant combined with concentrated platelet in infected surgical wounds: single-center prospective study

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