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Risk stratification in pediatric celiac disease

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Mark C. Wakeman, Peter A. Slavin, Ronaldo T. Gismondi¹*

 
 
 
Abstract

Gastrointestinal symptoms of celiac disease that characteristically appear at age 9-24 months. Symptoms begin at various times after the introduction of foods that contain gluten. Infants and young children typically present with chronic diarrhea, anorexia, and vomiting with other GI symptoms. These symptoms occur because the immune system responds abnormally to a protein (gluten) found in certain foods, like wheat, rye, barley, and prepared food. The small intestine is responsible for absorbing food and nutrients. Although celiac disease cannot be cured, strict avoidance of foods that contain gluten usually reverses the damage to the intestinal lining and stops associated symptoms. Understanding that immunological and genomic risk prediction is not deterministic but rather probabilistic provides the opportunity for disease prevention and targeted treatment in pediatric.

Keywords: Celiac disease; Gluten; Immune system

Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.

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DOI: http://dx.doi.org/10.18081/2333-5106/016-2/75-85
American Journal of BioMedicine Volume 5, Issue 3, pages 75-85
Received November 11, 2016; accepted January 07, 2017; published February 05, 2017

How to cite this article
Wakeman MC, Slavin PA, Gismondi RT. Risk stratification in pediatric celiac disease. American Journal of BioMedicine 2017;5(2):75-85.

Article outline
1. Abstract
2. Keywords
3. Introduction
4. Discussion
7. Acknowledgements
8. References

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