Advertisement

Epidemiological associations between diagonal earlobe crease and coronary artery disease: a comprehensive study

 
crossMark
 
Research Article  
dx.doi.org/10.18081/2333-5106/015-11/754-768
American Journal of BioMedicine Volume 3, Issue 11, pages 754-768
Received: July 09, 2015; accepted: October 03, 2015; published: October 27, 2015


 John N. Friedmana, Xing Zhaoa, b mail of corresponding author

Abstract

Degeneration of the elastic tissue around the small blood vessels that carry blood to the earlobes produces the earlobe crease. This is the same type of change in blood vessels associated with coronary artery disease (CAD). The visible changes that show up in tiny blood vessels of the ear could indicate similar changes in those blood vessels that can’t be seen around the heart. This study aimed to assess the associations of diagonal earlobe crease and age with coronary artery disease. A cohort of 1706 residents was enrolled in this study. Physical examinations and laboratory tests were performed following a standardized protocol. Diagonal earlobe crease was found in in people younger than age 40 was a sign of CAD in up to 80 percent of cases. Further, we found that the sensitivity and specificity was high regardless of age, except for specificity in male patients > 75 years old. These data suggest that a diagonal earlobe crease is associated with increased coronary artery disease morbidity and mortality. Patients with diagonal earlobe crease may be at higher risk for coronary events, and might be especially cautioned to control or reduce other cardiac risk factors.

Keywords: Diagonal earlobe crease; coronary artery disease; Earlobes; Elastic tissue

Copyright © 2015 by The American Society for BioMedicine and BM-Publisher, Inc.

ReferencesFull-Text/PDFFeedback

References

1. Brady PM, Zive MA, Goldberg RJ, et al. A new wrinkle to the earlobe crease. Arch Intern Med 1987;147(1):65-66. [Abstract/Full-Text]

2.  Shmilovich H, Cheng V, Rajani R, et al. Relation of Diagonal Ear Lobe Crease to the Presence, Extent, and Severity of Coronary Artery Disease Determined by Coronary Computed Tomography Angiography. American Journal of Cardiology 2012;109(9):1283 -1287. [PubMed]

3. Petrakis NL. Earlobe crease in women: evaluation of reproductive factors, alcohol use and quetelet index and relation to atherosclerotic disease. American Journal of Medicine 1995;99:356 – 61. [PubMed]

4. Marzolo M, Verlato F, Zotta L, Guadagnin ML, Borgese L, Cravatari M. Occult atherosclerosis and physical vascular examination: a simple strategy to avoid inadequate cardiovascular prevention and under-use of diagnostic vascular guidelines in outpatients A multicenter study by Angiology Care Units in North-Eastern Italy. Int Angiol. 2008;27:426–432. [PubMed]

5. Evrengül H, Dursunoğlu D, Kaftan A, Zoghi M, Tanriverdi H, Zungur M. Bilateral diagonal earlobe crease and coronary artery disease: a significant association. Dermatology 2004;209:271–27. [PubMed]

6. Edston E. The earlobe crease, coronary artery disease, and sudden cardiac death: an autopsy study of 520 individuals. Am J Forensic Med Pathol 2006;27:129–133. [PubMed]

7. Raman R, Rani PK, Kulothungan V, Sharma T. Diagonal ear lobe crease in diabetic south Indian population: is it associated with Diabetic Retinopathy. Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular-genetics Study (SN-DREAMS, Report no 3). BMC Ophthalmol 2009;9:11. [PubMed]

8. Cheng TO. More research needed on the association between diagonal earlobe crease and coronary artery disease. Arch Intern Med 2000;160:2396–2397. [PubMed]

9. Koracevic G, Atanaskovic V. Ear lobe crease: point of disagreement in evidence-based medicine. Am J Forensic Med Pathol 2009;30:89. [PubMed]

10. Higuchi Y, Maeda T, Guan JZ, Oyama J, Sugano M, Makino N. Diagonal earlobe crease are associated with shorter telomere in male Japanese patients with metabolic syndrome. Circ J.2009;73:274–279. [PubMed]

11. Doughan AK, Harrison DG, Dikalov SI. Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. Circ Res 2008;102(4):488–496. [PubMed]

12. Touboul PJ, Hernández-Hernández R, Küçükoğlu S, Woo KS, Vicaut E, Labreuche J. Carotid artery intima media thickness, plaque and Framingham cardiovascular score in Asia, Africa/Middle East and Latin America: the PARC-AALA study. Int J Cardiovasc Imaging 2007;23:557–567. [PubMed]

13. Friedlander AH. Association between clinically identified diagonal earlobe creases and calcified carotid artery atheromas evidenced on panoramic radiography. J Oral Maxillofac Surg 2010;68:227–228. [PubMed]

14. Johnsen SH, Mathiesen EB. Carotid plaque compared with intima-media thickness as a predictor of coronary and cerebrovascular disease. Curr Cardiol Rep 2009;11:21–27. [PubMed]

15. Kotsis VT, Pitiriga VCh, Stabouli SV, Papamichael CM, Toumanidis ST, Rokas SG. Carotid artery intima-media thickness could predict the presence of coronary artery lesions. Am J Hypertens 2005;18:601–606. [PubMed]

16. Edston E. The earlobe crease, coronary artery disease, and sudden cardiac death: an autopsy study of 520 individuals. Am J Forensic Med Pathol 2006;27(2):129-33. [PubMed]

17. Frank S. Aural sign of coronary-artery disease. N Engl J Med 1973;289:327–328. [PubMed]

18. Jorde LB, Williams RR, Hunt SC. Lack of association of diagonal earlobe crease with other cardiovascular risk factors. West J Med 1984;140:220–223. [PubMed]

19. Gutstein A, Dey D, Cheng V, et al. Algorithm for radiation dose reduction with helical dual source coronary computed tomography angiography in clinical practice. J Cardiovasc Comput Tomogr 2008;2:311–322. [PubMed]

20. Lichstein E, Chadda KD, Naik D, Gupta PK. Diagonal ear-lobe crease: prevalence and implications as a coronary risk factor. N Engl J Med 1974;290:615-616. [PubMed]

21. Evrengül H, Dursunoğlu D, Kaftan A, Zoghi M, Tanriverdi H, Zungur M. Bilateral diagonal earlobe crease and coronary artery disease: a significant association. Dermatol 2004;209:271-275. [PubMed]

22. Sapira JD. Earlobe creases and macrophage receptors. South Med J 1991;84:537-538. [PubMed]

Limited access article

limited access This article with limited access need to be buy, before continue with your purchase please read carefully the AJBM terms and conditions of purchase.

Purchase this article at rate $55.00 and received Full-Text/PDF
You will have online immediate access to article following the completion of this purchase and you may download and print a copy of each article for your personal use. Use the coding below to purchase your article as PDF by credit card, debit card, payball will be asked to supply your billing card information.

 

For any technique error please contact us and will be response to sending purchase article by email.

Thank you for visiting American Journal of BioMedicine.  * = Required fields

[gravityform id=”6″ name=”Feedback”]

American Journal of Biomedicine © 2017 Frontier Theme
%d bloggers like this: