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Experimental study: Hypoxia-Inducible Factor-1α/Notch1 in colorectal cancer modulates angiogenesis

"Research Article"

American Journal of BioMedicine  Volume 3, Issue 2, pages 88-99, February 2015


Vincent Xu; An Yan; Jing Luan;  Liang Chen; Betty Li; Nan Zhang 

Abstract

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. This is distinct from vasculogenesis, has significant relationship was detected in tumor angiogenesis of colorectal cancer. Hypoxia inducible factor-1 (HIF-1) is a transcription factor responsible for cellular and tissue adaptation to low oxygen tension. HIF-1 is a heterodimer consisting of a constitutively expressed β subunit and an oxygen-regulated α subunit, which primarily determines HIF-1 activation, and regulates a series of genes that participate in angiogenesis. The purpose of the present study was to investigate the association between HIF-1/Notch-1 and colorectal cancerangiogenesis. The levels of HIF-1/Notch-1 were significantly higher in patients with colorectal cancer (P<0.05). Further, these result were correlated with incresed the level of VEGF (Stage 3-4) (P<0.05). Therefore, targeting VEGF by suppressing hypoxia- and Notch-induced angiogenesis may benefit colorectal cancer therapy and larger studies with long-term follow-up are necessary to clarify this hypothesis.

Keywords: HIF-1; VEGF; Notch-1; colorectal; Angiogenesis


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