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Sepsis and signal transduction pathway: cross-talk TLR4/ MyD88/TRIF

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doi: 10.18081/ajbm/2333-5106/014-04/150-163     
American Journal of BioMedicine Volume 3, Issue 4, pages 150-163
Published: 09 April 2015

Lothar Rink; Takashi Hebel; Jimmy Fukumoto

Abstract

Sepsis is a consequence of infection that is difficult to predict, diagnose, and treat. Patients who develop sepsis have an increased risk of complications and death and face higher healthcare costs and longer treatment. LPS/TLR4 signaling has been intensively studied in the past few years. Still, it is poorly understood how the TLR-induced inflammatory and antiviral immune responses are balanced. Further, it’s unclear to identified molecules specifically involved in TLR signaling, where it differentially regulates MyD88 and TRIF signaling. Here we review molecules involved in TLR4-mediated signaling, including MyD88/TRIF pathway.

Keywords: Sepsis; LPS; MyD88; Proinflammatroy cytokines


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