Anti-diabetic activity and hepatoprotective effect of Chrozophora tinctoria (L.) Rafin leaves aqueous extract in STZ induced diabetic rats’ model


 

Abstract

The responses of streptozotocin (STZ)-induced diabetic rats for the aqueous Chrozophora tinctoria (L.) Rafin leaves extracts were studied in this new work. To achieve this aim, Physiological, biochemical and histological parameters of (STZ) diabetic rats are evaluated. Rats are distributed into five groups: Control, diabetic rats and three diabetic groups received orally different doses of (50, 70, and 90 mg/kg body weight (BW)) from the target extract for a period of 35 days. When the therapy is ended, blood samples, liver tissues were taken and glucose, insulin, ALT, AST, ALP were determined as well as liver histology. In general, the results of this study show that the liver tissue damage serum ALP, AST ALT activities and blood glucose levels were remarkable normalized. Furthermore, it was observed that the BW of diabetic control group is decreased. However, the BW is elevated slightly in the diabetic treated groups as well as serum insulin. In addition, the extract improves the liver function and reduces lesions associated with diabetic state in STZ induced rats. Moreover, the effect of oral administration of Chrozophora tinctoria (L.) Rafin at a dose of 90 mg / kg body weight was more efficacy than the 50 and 70 mg/kg body weight. The results indicate the extract exhibit protective effect on liver tissues, and prove its potentials as an antidiabetic and hepatoprotective agent.

Keywords: Chrozophora tinctoria (L.) Rafin; Diabetes; Streptozotocin; Liver function

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Research Article
DOI: http://dx.doi.org/10.18081/2333-5106/018-12/755-775
American Journal of BioMedicine Volume 6, Issue 12, pages 755-775
Received October 02, 2018; accepted December 01, 2018; published December 10, 2018

How to cite this article
Auda MA, Saoudi MH. Anti-diabetic activity and hepatoprotective effect of Chrozophora tinctoria (L.) Rafin leaves aqueous extract in STZ induced diabetic rats model. American Journal of BioMedicine 2018;6(12):755-775.

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