Clomiphene citrate or letrozole for ovulation induction in infertile polycystic ovarian syndrome women

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 Alaa Mohammed Sadeq¹, Sarah Majeed Kareem

Polycystic ovary syndrome (PCOS) is associated with anovalation and a common cause of infertility, Clomiphene citrate has traditionally used as a drug of choice in treating women with anovulatory PCOS,  in the last decade letrozole, an aromatase inhibitor has emerged as an alternative ovulation induction agent. The objective of this study is to compare the effects of letrozole and clomiphene citrate as an ovulation induction drug in subfertile PCOS women. The subfertile PCOS women were treated randomly with 5 mg letrozole or 100mg clomiphene citrate from day 3 menstrual cycle for 5 days. The main outcome of this study are: ovulation rate; mono or multi follicular rate; days to ovulation; endometrial thickness; and serum estradiol levels and pregnancy rate. Letrozole group was higher in number of responsive when compared with CC group but still not significant. In letrozole group the number of monofollicle cycle was higher (69.57%) and multifollicles cycle was low (30.43%) when are comparing with that of CC group. In conclusion, letrozole in patients with PCOS is as effective as clomiphene citrate in inducing ovulation, ovulation rate and the incidence of pregnancy was higher with letrozole than that with clomiphene citrate. A part from that, letrozole treatment is prone to a production of monofollicles.

Keywords: Letrozole; Clomiphene citrate; Polycystic ovary syndrome

Copyright © 2016 Sadeq AM et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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DOI: 10.18081/2333-5106/016-11/455-465

Cited by in Scopus

Research Article
American Journal of BioMedicine Volume 4, Issue 11, pages 455-465
Received June 21, 2016; accepted October 12, 2016; published November 18, 2016

How to cite this article
Sadeq AM, Kareem SM. Clomiphene citrate or letrozole for ovulation induction in infertile polycystic ovarian syndrome women. American Journal of BioMedicine 2016;4(11):455-465.

Article outline
1. Abstract
2. Keywords
3. Introduction
4. Materials and Methods
5. Results
6. Discussions
7. Acknowledgements
8. References

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