Ivor A. Benjamin¹, Toshio Higashi, Silvana Hrelia∗
Myocardial ischemia and reperfusion injury (I/R) is a common cause of myocardial injury following cardiac operations and intervention leading to an induction of oxidative stress, cellular dysfunction and depressed of cardiac function. DNA damage, including oxidative base modifications and physical DNA strand breaks, is a consequence of myocardial I/R. Like many other organs in the body, a redundant and highly conserved set of endogenous repair pathways have evolved to selectively recognize the various types of cellular DNA damage and combat its negative effects on cell viability. Severe damage to the DNA, however, can trigger cell death and elimination of the injured myocytes. In this study, we will organized the state of the current field of DNA damage and repair in the myocardium, and provide some expected and in some cases, unexpected results with regards to their response following myocardial I/R and could provide new opportunities for cardiac research.
Keywords: Myocardial ischemia/reperfusion; DNA damage; Cardiac function
Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.
- Beinsden PR, Balen AH. Textbook of Invitro Fertilization and Asisted Reproduction. 3rd edition, 2007:189-215.
- Singal PK, Bello-Klein A, Farahmand F, Sandhawalia V. Oxidative stress and functional deficit in diabetic cardiomyopathy. Adv Exp Med Biol. 2001;498:213–20. [PubMed]
- Perreault S, Dragomir A, Roy L, et al. Adherence level of antihypertensive agents in coronary artery disease. Br J Clin Pharmacol. 2010;69:74–84. [PubMed]
- Ho KK, Levy D, Kannel WB, Pinsky JL. The epidemiology of heart failure: The Framingham study. J Am Coll Cardiol. 1993;22:6–13. [PubMed]
- Chen H, Azuma M, Maeda K, Kajimoto N, Higashino H. Impaired heart function and noradrenaline release after ischaemia in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 2000;27:664–70. [PubMed]
- Austin EW, Yousif NG, Ao L. Ghrelin reduces myocardial injury following global ischemia and reperfusion via suppression of myocardial inflammatory response. American Journal of BioMedicine 2013;1(2):38-48. [PubMed]
- Downey JM, Davis AM, Cohen MV. Signaling pathways in ischemic preconditioning. Heart Fail Rev 2007;12:181–8. [PubMed]
- Loubani M, Hassouna A, Galinanes M. Delayed preconditioning of the human myocardium: Signal transduction and clinical implications. Cardiovasc Res. 2004;61:600–9. [PubMed]
- Ferdinandy P, Schulz R, Baxter GF. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev. 2007;59:418–58. [PubMed]
- Akita Y, Otani H, Matsuhisa S, et al. Exercise-induced activation of cardiac sympathetic nerve triggers cardioprotection via redox-sensitive activation of eNOS and upregulation of iNOS. Am J Physiol Heart Circ Physiol. 2007;292:H2051–9. [PubMed]
- Wan S, DeSmet JM, Barvais L, Golstein M, Vincent JL, LeClerc JL. Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg 1996;112: 806–811. [PubMed]
- Eberhardt F, Mehlhorn U, Larose K, DeVivie ER, Dhein S. Structural myocardial changes after coronary artery surgery. Eur J Clin Invest 2000;30: 938-946. [PubMed]
- Verma S, Fedak PW, Weisel RD, et al. Off-pump coronary artery bypass surgery: fundamentals for the clinical cardiologist. Circulation 2004;109:1206-1211. [PubMed]
- Petzelbauer P, Zacharowski PA, Miyazaki Y, et al. The fibrin-derived peptide B beta15–42 protects the myocardium against ischemia–reperfusion injury. Nat Med 2005;11:298-304.
- Jordan JE, Zhao ZQ, Vinten-Johansen J. The role of neutrophils in myocardial ischemia–reperfusion injury. Cardiovasc Res 1999;43: 860–878. [PubMed]
- Franke A, Lante W, Fackeldey V, et al. Pro-inflammatory cytokines after different kinds of cardio-thoracic surgical procedures: is what we see what we know. Eur J Cardiothorac Surg 2005;28:569-575.
- Yousif NG, Al-Amran FG. Novel Toll-like receptor-4 deficiency attenuates trastuzumab (Herceptin) induced cardiac injury in mice. BMC Cardiovasc Disord 2011;11:62. [PubMed]
- Slimani H, Zhai Y, Yousif NG, Ao L, Zeng Q, Fullerton DA, Meng X. Enhanced monocyte chemoattractant protein-1 production in aging mice exaggerates cardiac depression during endotoxemia. Crit Care 2014;18(5):527. [PubMed]
- Lindmark E, Diderholm E, Wallentin L, et al. Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or non-invasive strategy. JAMA 2001;286:2107–13. [PubMed]
- Williams RS, Benjamin IJ. Protective responses in the ischemic myocardium. J Clin Invest 2000;106:813–8. [PubMed]
- Pockley AG. Heat shock proteins as regulators of the immune response. Lancet 2003;362:469–76. [PubMed]
- Frantz S, Kobzik L, Kim Y-D, et al. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest 1999;104:271–80. [PubMed]
- Heeschen C, Dimmeler S, Hamm CW. Serum level of the antiinflammatory cytokine interleukin-10 is an important prognostic determinant in patients with acute coronary syndromes. Circulation 2003;107:2109–14. [PubMed]
- Zhai Y, Ao L, Yousif N, Al-amran F, Fullerton D, Meng X. TLR4 mediates the inflammatory response of remote non-ischemic myocardium and contributes to heart failure in a mouse model of myocardial infarction. SHOCK 2013;39:29.
- Prabhu SD. Cytokine-induced modulation of cardiac function. Circ Res 2004;95:1140–1153. [PubMed]
- Kumar A, Haery C, Parrillo JE. Myocardial dysfunction in septic shock. Crit Care Clin 2000;16:251–287. [PubMed]
- Mittal R, Coopersmith CM. Redefining the gut as the motor of critical illness. Trends Mol Med 2014;20:214–223.[PubMed] [Cross Ref]
- Nishida K, Okinaga K, Miyazawa Y, et al. Emergency abdominal surgery in patients aged 80 years and older. Surg Today 2000;30:22–27. [PubMed]
- Yousif NG, Li J, Yousif F, et al. Expression of IL-37 in mouse protects the myocardium against ischemic injury via modulation of NF-κB activation. Circulation 2011;124(Suppl 21):A8603.
READ THE FULL ARTICLE
1. Access this article through OpenAthens
3. Purchase this article at rate $55.00 and received Full-Text/PDF
You will have online immediate access to article following the completion of this purchase and you may download and print a copy of each article for your personal use. Use the coding below to purchase your article as PDF by credit card, debit card, will be asked to supply your billing card information. Before continue with your purchase please read carefully the BM-Publisher terms and conditions of purchase.
For any technique error please contact us and will be response to sending purchase article by email.
Who Can Become a Reviewer?
Any expert in the article's research field can become a reviewer with American Journal of Biomedicine. Editors might ask you to look at a specific aspect of an article,...
Thank you for visiting American Journal of BioMedicine. * = Required fields
[contact-form-7 404 "Not Found"]
American Journal of BioMedicine Volume 4, Issue 11, pages 466-479
Received June 02, 2016; accepted October 19, 2016; published November 24, 2016
How to cite this article
Benjamin IA, Higashi T, Hrelia S. Potential role of DNA repair in myocardial injury following ischemia and reperfusion. American Journal of BioMedicine 2016;4(11):466-479.
4. Materials and Methods