Differences in the survival rate between premenopausal and postmenopausal women with lung cancer: US SEER database

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Nasser Ghaly Yousif, Christian Schumann^1*

∗Correspondence author e-mail: Christian Schumann@ ulm.edu: ¹Department of Clinic of Internal Medicine II, Ulm, Baden-Württemberg, Germany

Abstract

In the United State, lung cancer remains the leading cause of cancer death in both men and women. Several reports have suggested a role for estrogens in the development and/or progression of lung cancer, especially in women. Data from the national SEER registry between the years of 1990-2011 was analyzed, women between the ages 31-50 years old were chosen as representative of the premenopausal group (n=1595) and 51-70-year-old women represented the postmenopausal group (n=7075) as defined by the American College of Obstetricians and Gynecologists. For comparison, men were divided into two categories: younger men (n=2233) aged 31- 50 years and older men (n=10908) aged 51-70 years. Survival rates were analyzed by Kaplan-Meier method and compared by Z-test through SEER*Stat software version 7.0.9. The adenocarcinoma had a significant difference between premenopausal and postmenopausal groups (62% vs. 51%) respectively. Furthermore, the survival rate in premenopausal inferior to postmenopausal women in both SCC and BAC P<0.05. Premenopausal women more commonly underwent curative surgery, 42%, and 19% of postmenopausal women treated palliative. Additionally, for every stage of disease, 55% of postmenopausal women have radiotherapy. The results suggest varying estrogen effects between the histology sub-types of NSCLC and support clinical strategies need to block the ER pathway for the treatment of NSCLC.

Keywords: NSCLC; SEER; Estrogens; Premenopause; Postmenopause; Survival rate

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