Received March 01, 2017; Accepted June 30, 2017; Published August 11, 2017
http://dx.doi.org/10.18081/2333-5106/015-05/220-231
Mark Fernandez Bedoya; Maria A. Hegeman; Marchil G. Rovere; Amanda Bron; Jimmy Fukumoto
Abstract
Human immunodeficiency virus (HIV) is still an important public health problem that emerged in the world. It is estimated that globally about 37.9 million people are living with this virus. Our country, South Africa, is one of the countries that have the most cases of people living with HIV. It is estimated that about 19% of the adult population (20-49 years) are affected by this virus. The aim of this study is to evaluate the role of IL-8 polymorphisms in HIV patients and in healthy people in South Africa. The production of IL-8 may have changed with some polymorphisms, and these changes may be responsible for the prognosis of HIV patients. If something is determined about these polymorphisms, it can be a basis for new preventive and regenerative therapies in HIV.
HIV, which is a pandemic infection-related disease, eventually causes communities to become vulnerable. This is a major problem in developing countries because they have low-income public status. Many advances have been made in the treatment of HIV, but there are still health problems because there is nothing like a complete treatment. The World Health Organization (WHO) reports that more than 25 million people have died from AIDS from 1981 to 2018. HIV/AIDS epidemiological reports state that the HIV/AIDS pandemic has affected both developing and developed countries. South Africa has the highest number of people living with HIV in the world. It is also the country with the highest number of AIDS-related deaths in the world. Most of these deaths are due to co-infections with biotic and abiotic infections and due to the pathogenesis of long-term disease progression. The role of the cytokine IL-8 has been described in many infectious and inflammatory diseases, some of which are caused by severely immunosuppressive pathogens. One IL-8 polymorphism, rs2227306, has been associated with long-term disease progression in HIV-infected individuals. The current study was aimed at determining whether the IL-8 polymorphisms had an association with HIV disease progression in South African HIV-infected individuals. Data from a pilot study was used to analyze the association of the polymorphisms with HIV viral load and CD4+ cell counts.
Keywords: Interleukin-8 (IL-8); Cytokine; HIV; Polymorphism
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