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Brazil is a country with a significant burden of chronic kidney disease (CKD). Renal failure is rarely diagnosed in developed countries as a result of available clinical and laboratory development, as glomerular filtration rate (GFR) can be easily and cheaply estimated by a simple equation based on serum levels of creatinine. This approach allows CKD to be diagnosed earlier, prevents harmful medications in renal patients, and suggests medication adjustments to avoid nosocomial effects. The objective of this study is assessing the performance of validated GFR estimating equations in Brazil and its consequences for the diagnosis and prognosis of CKD. To diagnose the degree of renal function, the main equation used in Brazil is the one developed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), which allows simultaneous assessment of GFR, serum creatinine, and eGFR, which are used in relation to cardiovascular events and mortality. As opposed to the white confirmed equation, CKD-EPI did not show a lower relationship with calciuria, albuminuria, proteinuria, and mortality. Additionally, CKD-EPI does not show diagnostic accuracy for detecting the degree of renal failure in the TC-CD, hemocessation, and the fat accumulation as AR. Despite this, CKD-EPI has a lower diagnostic success for awareness of GFR < 90 ml/min/1.73m2. This may be one of the reasons for the relatively increased prevalence of hemorrhagic hematocrit and malignancies in patients with CKD.
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