Adult cerebellar glioblastoma: case report and review of the literature


Downloads: 93
Gabriel Castelluccio, Gonzalo Bertullo, Rafael De Armas*
Author Affiliations
∗Correspondence author e-mail: Rafael1961@yahoo.com: 1 Faculty of Medicine, Universidad de la República, Montevideo, Uruguay.

 

 

 

Abstract

The purpose of this study was to emphasize that cerebellar glioblastoma multiforme, although quite rare, should be included in the differential diagnosis of tumors of the posterior cranial fossa in adults. The cerebellum has been known to be the site of predilection of hemangioblastoma, medulloblastoma, metastasis, and pilocytic astrocytoma. Very few adult cerebellar glioblastoma have been reported previously. We present a case and discuss the neuroradiologic and pathologic features of this interesting location of these highly malignant tumors, which are diagnosed radiologically to be meningioma, hemangioblastoma, or metastasis. In the present case, a solitary mass was detected and interpreted as a meningioma on a magnetic resonance image (MRI) with gadolinium. Repeated follow-up studies and histologic confirmation by image-guided stereotactic biopsy were important for the diagnosis, since glioblastoma was unsuspected at the onset. Establishment of the cell of origin is of critical importance for planning therapy and prognostication. The absence of what today is considered evidence-based medicine to treat high-grade gliomas, coupled with the rare occurrence at this location, indicates that cerebellar glioblastoma has to be differentiated from other tumors without delay upon radiologic diagnosis.

Keywords: Cerebellar glioblastoma; Treatment modalities; Prognostic factors; Outcome

Copyright © 2020 by The American Society for BioMedicine and BM-Publisher, Inc.

Article citationReferencesBecome reviewer
The citation data is computed by the following citation measuring services:

Google scholarcitedby

References

  1. Demir MK, Hakan T, Akinci O, Berkman Z. Primary cerebellar glioblastoma multiforme. Diagn Interv Radiol 2005;11:83-86.
  2. Lakičević G, Arnautović K, Mužević D, Chesney T. Cerebellar glioblastoma multiforme presenting as hypertensive cerebellar hemorrhage: case report. J Neurol Surg Rep 2014;75:e117-e121.
    https://doi.org/10.1055/s-0034-1376198
  3. Grahovac G, Tomac D, Lambasa S, et al. Cerebellar glioblastomas: pathophysiology, clinical presentation and management. Acta Neurochir (Wien) 2009;151:653-657.
    https://doi.org/10.1007/s00701-009-0286-5
  4. Linsenmann T, Monoranu CM, Vince GH, et al. Long-term tumor control of spinal dissemination of cerebellar glioblastoma multiforme by combined adjuvant bevacizumab antibody therapy: a case report. BMC Research Notes 2014;7:496.
    https://doi.org/10.1186/1756-0500-7-496
  5. Gopalakrishnan CV, Dhakoji A, Nair S, Menon G, Neelima R. A retrospective study of primary cerebellar glioblastoma multiforme in adults. Journal of Clinical Neuroscience 2012;19:1684-1688.
    https://doi.org/10.1016/j.jocn.2011.12.035
  6. Urbańska K, Sokołowska J, Szmidt M, Sysa P. Glioblastoma multifo-rme: an overview. Contemp Oncol (Pozn) 2014;18(5):307-312.
    https://doi.org/10.5114/wo.2014.40559
  7. Stark AM, Maslehaty H, Hugo HH, Mahvash M, Mehdorn HM. Glioblastoma of the cerebellum and brain stem. Journal of Clinical Neuro-science 2010;17:1248-1251.
    https://doi.org/10.1016/j.jocn.2010.02.015
  8. Montaudon M, Latrabe V, Iriart X, Caix P, Laurent F. Congenital coronary arteries anomalies: review of the literature and multidetector computed tomography (MDCT)-appearance. Surg Radiol Anat 2007;29(5):343-55.
    https://doi.org/10.1007/s00276-007-0217-1
  9. Hess KR, Broglio KR, Bondy ML. Adult glioma incidence trends in the United States, 1977-2000. Cancer 2004;101:2293-2299.
    https://doi.org/10.1002/cncr.20621
  10. Modan B, Wagener DK, Feldman JJ, Rosenberg HM, Feinleib M. Increased mortality from brain tumors: a combined outcome of diagnostic technology and change of attitude toward the elderly. Am J Epidemiol 1992;135:1349-1357.
    https://doi.org/10.1093/oxfordjournals.aje.a116246
  11. Adams H, Chaichana KL, Avendaño J, Liu B, Raza SM, Quiñ-ones-Hinojosa A. Adult cerebellar glioblastoma: understanding survival and prognostic factors using a population-based database from 1973 to 2009. World Neurosurgery 2013;80(6):e237-e243.
    https://doi.org/10.1016/j.wneu.2013.02.010
  12. Utsuki S, Oka H, Miyajima Y, Kijima C, Yasui Y, Fujii K. Adult cerebellar glioblastoma cases have different characteristics from supratentorial glioblastoma. Brain Tumor Pathol 2012;29:87-95.
    https://doi.org/10.1007/s10014-011-0070-0
  13. Jing X, Shen G, Su M, Tian R, Jia Z. Primary glioblastoma of the cerebellar vermis: A case report. Onc-ology Letters 2015;10:402-404.
    https://doi.org/10.3892/ol.2015.3188
  14. Tsung AJ, Prabhu SS, Lei X, Chern JJ, Benjamin N, Shonka NA. Cerebellar glioblastoma: a retrospective review of 21 patients at a single institution. J Neurooncol 2011;105: 555-562.
    https://doi.org/10.1007/s11060-011-0617-2
  15. Babu R, Sharma R, Karikari IO, Owens TR, Friedman AH, Adamson C. Outcome and prognostic factors in adult cerebellar glioblastoma. Journal of Clinical Neuroscience 2013;20:1117-1121.
    https://doi.org/10.1016/j.jocn.2012.12.006
  16. Jeswani S, Nuño M, Folkerts V, Mukherjee D, Black KL, Patil CG. Comparison of survival between cerebellar and supratentorial glioblastoma patients: Surveillance, Epidemiology, and End Results (SEER) analysis. Neurosurgery 2013;73:240-246.
    https://doi.org/10.1227/01.neu.0000430288.85680.37
  17. Dohrmann GJ, Dunsmore RH. Glioblastoma multiforme of the cerebellum. Surg Neurol 1975;3:21 9-223.
    18. Kuroiwa T, Numaguchi Y, Rothman MI, et al. Posterior Fossa Glioblastoma Multiforme: MR Findings. AJNR Am J Neuroradiol 1995;16:583-589.
  18. Levine SA, McKeever PE, Greenberg HS. Primary cerebellar glioblastoma multiforme. J Neurooncol 1987;5:231-236.
    https://doi.org/10.1007/BF00151226
    20. Djalilian HR, Hall WA. Malignant gliomas of the cerebellum: an analytic review. J Neurooncol 1998;36:247-257.
    https://doi.org/10.1023/A:1005704006244
  19. Kast RE. Why cerebellar glioblastoma is rare and how that indicates adjunctive use of the FDA-approved antiemetic aprep-itant might retard cerebral glioblastoma growth: a new hypothesis to an old question. Clin Transl Onc ol 2009;11:408-410.
    https://doi.org/10.1007/s12094-009-0379-x
  20. Mattos JP, Marenco HA, Campos JM, et al. Cerebellar glioblastoma multiforme in an adult. Arq Neuro-psiquiatr 2006;64(1):132-135.
    https://doi.org/10.1590/S0004-282X2006000100028
  21. Hamilton MG, Tranmer BI, Hagen NA. Supratentorial glioblastoma with spinal cord intramedullary metastasis. Can J Neurol Sci 2003;20:65-8.
    https://doi.org/10.1017/S0317167100047454
  22. Vertosick Jr FT, Selker RG. Brain stem and spinal metastases of supratentorial glioblastoma multiforme: a clinical series. Neurosurgery 1990;27:516-21.
    https://doi.org/10.1227/00006123-199010000-00002
  23. Wisoff HS, Llena JF. Glioblastoma multiforme of the cerebellum five decades after irradiation of a cerebellar tumor. J Neurooncol 1989;7:339-344.
    https://doi.org/10.1007/BF02147091
  24. Schmidbauer M, Budka H, Bruck-ner R, Vorkapic P. Glioblastoma developing at the site of a cerebellar medulloblastoma treated 6 years earlier: case report. J Neurosurg 1987;67:915-918.
    https://doi.org/10.3171/jns.1987.67.6.0915
  25. Ushio Y, Arita N, Yoshimine T, Ikeda T, Mogami H. Malignant recurrence of childhood cerebellar astrocytoma: case report. Neuro-surgery 1987;21:251-255.
    https://doi.org/10.1097/00006123-198708000-00025
  26. Maat-Schieman ML, Bots GT, Tho-meer RT, Vielvoye GJ. Malignant astrocytoma following radiotherapy for craniopharyngioma. Br J Radiol 1985;58:480-482.
    https://doi.org/10.1259/0007-1285-58-689-480
  27. Hur H, Jung S, Jung TY, Kim IY. Cerebellar Glioblastoma Multiforme in an Adult. J Korean Neuro-surg Soc 2008;43:194-197.
    https://doi.org/10.3340/jkns.2008.43.4.194
  28. Kawarabuki K, Ohta T, Hashimoto N et al. Cerebellar glioblastoma genetically defined as a secondary one. Clin Neuropathol 2005;24:64-68.
  29. Saito T, Hama S, Kajiwara Y et al. Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas. Anticancer Res 2006;26:1351-1357.
  30. Capper D, Weissert S, Balss J et al. Characterization of R132H muta-tion specific IDH1 antibody binding in brain tumors. Brain Pathol 2010;20:245-254.
    https://doi.org/10.1111/j.1750-3639.2009.00352.x
  31. Watanabe K, Tachibana O, Sata K et al. Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol 1996; 6:217-224.
    https://doi.org/10.1111/j.1750-3639.1996.tb00848.x
  32. Weber DC, Miller RC, Villa S, et al. Outcome and prognostic factors in cerebellar glioblastoma multiforme in adults: a retrospective study from the rare cancer network. Int J Radiat Oncol Biol Phys 2006;66: 179-186.
    https://doi.org/10.1016/j.ijrobp.2006.04.035
  33. Akimoto J, Fukami S, Tsutsumi M et al. Radiopathological characteristics of cerebellar malignant glioma in adults. Brain Tumor Pathol 2009;26:59-68.
    https://doi.org/10.1007/s10014-009-0248-x
  34. Barker FG, Simmons ML, Chang S, et al. EGFR overexpression and radiation response in glioblastoma multiforme. Int J Radiat Oncol Biol Phys 2001;51:410-418.
    https://doi.org/10.1016/S0360-3016(01)01609-1
  35. Pang D, Ashmead JW. Extraneural metastasis of cerebellar glioblastoma multiforme. Neurosurgery 1982;10(2):252-257.
    https://doi.org/10.1227/00006123-198202000-00013
  36. El Maaqili MR, Hossini A, El Fatemi N, et al. Primary glioblastoma of the cerebellum in a 19-year-old- woman: a case report. Journal of Medical Case Reports 2012;6: 329.
    https://doi.org/10.1186/1752-1947-6-329
  37. Zito JL, Siva A, Smith TW, Leeds M, Davidson R. Glioblastoma of the cerebellum. Computed tomographic and pathologic considerations. Surg Neurol 1983;19:373-378.
    https://doi.org/10.1016/0090-3019(83)90248-3
  38. Law M, Cha S, Knopp EA, Johnson G, Arnett J, Litt AW. High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR Imaging. Radiology 2002;222:715-721.
    https://doi.org/10.1148/radiol.2223010558
  39. Chaichana K, Parker S, Olivi A, Quiñones-Hinojosa A. A proposed classification system that projects outcomes based on preoperative variables for adult patients with glioblastoma multiforme. J Neurosurg 2010;112:997-1004.
    https://doi.org/10.3171/2009.9.JNS09805
  40. Laws ER, Parney IF, Huang W, et al. Glioma outcomes investigators: survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project. J Neurosurg 2003;99:467-473.
    https://doi.org/10.3171/jns.2003.99.3.0467
  41. Bi WL, Chiocca EA. Adult Cerebellar Glioblastomas: A Distinct entity or parcel of the whole? World Neurosurg 2013;80,6:e181-e183.
    https://doi.org/10.1016/j.wneu.2013.03.040
  42. Stupp R, Mason WP, van den Bent MJ, et al. European organization for research and treatment of cancer brain tumor and radiotherapy groups; national cancer institute of Canada Clinical Trials Group: radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987-996.
    https://doi.org/10.1056/NEJMoa043330
  43. Grossman SA, Ye X, Piantadosi S, Desideri S et al. NABTT CNS Consortium. Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States. Clin Cancer Res 2010;16:2443-2449.
    https://doi.org/10.1158/1078-0432.CCR-09-3106
  44. Kaur G, Bloch O, Jian BJ, et al. A critical evaluation of cystic features in primary glioblastoma as a prognostic factor for survival. J Neur-osurg 2011;115:754-759.
    https://doi.org/10.3171/2011.5.JNS11128
  45. Yang S, Liu J, Wang T, Li X, You C. Cerebellar glioblastoma multi-forme: a retrospective study of 28 patients at a single institution. International Joumal of Neuroscience 2013;123(10):691-697.
    https://doi.org/10.3109/00207454.2013.791292
  46. Giese A, Bjerkvig R, Berens ME, Westphal M. Cost of migration: invasion of malignant gliomas and implications for treatment. J Clin Oncol 2003;21:1624-1636.
    https://doi.org/10.1200/JCO.2003.05.063

Who Can Become a Reviewer?
Any expert in the article's research field can become a reviewer with American Journal of Biomedicine. Editors might ask you to look at a specific aspect of an article,...

Find out more

Article Review


DOI: http://dx.doi.org/10.18081/2333-5106/016-3/42-53
American Journal of BioMedicine 2020, Volume 8, Issue 1, pages 1-12
Received October 12, 2019; Accepted December 02, 2019; Published January 03, 2020

How to cite this article
Matsuda SM, Nakamura J, Eikan S, et al. XIAP expression attenuated myocardial injury in aging hearts after myocardial ischemia and reperfusion in mice model. American Journal of BioMedicine 2020;8(1):1-12
Article Review
1. Abstract
2. Keywords
3. Introduction
4. Discussion
5. References

Article metric