Diabetes and depression in atherosclerosis individuals at high cardiovascular risk

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American Journal of BioMedicine  Volume 2, Issue 8, pages 952-963, August 2014

Linda  N. Gregg; Lawrence Ford; Edward Gerstein


Diabetes mellitus is a major cause of death and disability worldwide and is a strong risk factor for stroke and independently predicts coronary atherosclerosis. The projective of this study is to analyze whether depression may influence the control of diabetes individuals at high cardiovascular risk. It is apparent that a variety of adaptations/alterations in cardiac structure and function occur as excessive uncontrol diabetes, even in the absence of comorbidities. PubMed MEDLINE was systematically searched for prospective population-based cohort studies published between on January 1, 2001 and January 1, 2013, of 4628 diabetes patients with high cardiovascular risk factor profiles. The relationship between diabetes and depression was analyzed. A multivariate analysis (logistic and log-linear regression), adjusting for potential confounders (socio-demographic factors, body mass index, lifestyle, diabetes, dyslipidemia), was performed. The pooled maximal-adjusted RR of stroke associated with diabetes was 2.32 (95% confidence interval [CI]:1.94, 2.86) in depression and 1.62 (1.51, 2.02) in non-depression. Together with these results the excess risk of cardiovascular risk associated with diabetes is significantly higher in depressant patients and need for further work to clarify the behavioral mechanisms that are involved.

Keywords: Diabetes mellitus; Coronary atherosclerosis; Cardiovascular risk; Depression

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