Research Article
American Journal of BioMedicine
Volume 10, Issue 2, 2022, Pages 82-91 | http://dx.doi.org/10.18081/2333-5106/2022.10/82
Yi-Wen Chen, Xiaochang Liu, Yao Dong 1
Received 22 March 2022; Revised 03 April 2022; Accepted 20 May 2022; Published 01 June 2022
Abstract
Hypertension is one of the major risk factors for cardiovascular morbidity and morbidity since high blood pressure can cause damage to microvascular and macrovascular organs. The Sixty non-smoker participants were divided into two main groups. Thirty participants group with high-intensity aerobic exercise and a second thirty group with moderate-intensity aerobic exercise. The electrical treadmill exercise is used three times per week for eight for each 25-30 minutes. Peripheral arterial blood pressure measurements and blood investigation in the form of serum uric acid and renal function tests were tested for each participant. The resulting data showed a significantly decreased effect on both serum uric acid and renal function tests in high-intensity intervals and continuous moderate exercise with more improvement with continuous moderate exercise 16% in serum uric acid and 27.5 % in creatinine. In conclusion, moderate continuous exercise reduces serum uric acid and creatinine better than high-intensity interval exercise. Both have the same effect on blood pressure and urea, but moderate continuous exercise has a crystal-clear effect that cannot be denied.
Keywords: Hypertension; Serum uric acid; Arterial blood pressure; Aerobic exercise
Copyright © 2022 Yao Dong et al. This article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
| 1. Schroeder EC, Franke WD, Sharp RL, Lee D Chul. Comparative effectiveness of aerobic, resistance, and combined training on cardiovascular disease risk factors: A randomized controlled trial. PLOS One. 2019; 14(1):1-14. https://doi.org/10.1371/journal.pone.0210292 |
||||
| 2. Dimeo F, Pagonas N, Seibert F, Arndt R, Zidek W, Westhoff TH. Exercise in Resistant Hypertension Aerobic Exercise Reduces Blood Pressure in Resistant Hypertension. AHA Journals. 2012; 6:653-58. https://doi.org/10.1161/HYPERTENSIONAHA.112.197780 |
||||
| 3. Huang L-L, Huang C-T, Chen M-L, Mao IF. Effects of Profuse Sweating Induced by Exercise on Urinary Uric Acid Excretion in a Hot Environment. Chin J Physiol. 2010; 53(4):254-61. https://doi.org/10.4077/CJP.2010.AMK060 |
||||
| 4. Gunjal S, Shinde N, Kazi A, Khatri S. Effect of Aerobic Interval Training on Blood Pressure and Myocardial function in Hypertensive Patients. Int J Pharm Sci Invent. 2013; 2(6):27-31. | ||||
| 5. Mazidi M, Katsiki N, Mikhailidis DP, Banach M. The Link Between Insulin Resistance Parameters and Serum Uric Acid Is Mediated by Adiposity. Atherosclerosis. 2018; 270:180-6. https://doi.org/10.1016/j.atherosclerosis.2017.12.033 |
||||
| 6. Estrada Araoz EG, Mamani Uchasara HJ, Gallegos Ramos NA. Estrate - gias psicoeducativas para el desarrollo de habilidades sociales en es - tudiantes peruanos de educación primaria. Archivos venezolanos de farmacología y terapéutica. 2020; 39(6):709-13. | ||||
| 7. Ramírez-Coronel AA, Cárdenas-Castillo PF, Martínez-Suárez PC, et al. Cárdenas-Cordero AJ. Impacto psicológico del confinamiento por COVID-19 hacia un nuevo constructo clinimétrico ansioso-depresivo en mujeres adultas de Azogues. Archivos Venezolanos de Farmacolo - gia y Terapéutica. 2020; 39(8):923-34. | ||||
| 8. Hong S, Lee Dong Geon, Lee Gyu Chang. Effect of aerobic exercise on blood pressure and arterial compliance in patients with essential hypertension. Journal of Exerc Physiol. 2018; 21(5). | ||||
| 9. Maruf FA, Akinpelu AO, Salako BL. A randomized controlled trial of the effects of aerobic dance training on blood lipids among individuals with hypertension on a thiazide. High Blood Press Cardiovasc Prev. 2014; 21:275-83. https://doi.org/10.1007/s40292-014-0063-2 |
||||
| 10. Ramos RM, Coelho-Junior HJ, Ramos do Prado RC, Silveira da Silva R, Asano RY, Prestes J, Medeiros Alexandre IA, Rodrigues B, et al. Mod - erate aerobic training decreases blood pressure but no other cardio - vascular risk factors in hypertensive overweight/obese elderly patients. Gerontol Geriatr Med. 2018; 4:1-8. https://doi.org/10.1177/2333721418808645 |
||||
| 11. Bernal JA, Quilis N, Andrés M, Sivera F, Pascual E. Gout: Optimizing Treatment to Achieve a Disease Cure. Ther Adv Chronic Dis. 2016; 7(2):135-44. https://doi.org/10.1177/2040622315618393 |
||||
| 12. Harshfield GA, Yan DB, Kapuku GK, et al. Stress-induced sodium retention and hypertension: a review and hypothesis. Curr Hypertens Rep. 2009; 11:29-34. https://doi.org/10.1007/s11906-009-0007-8 |
||||
| 13. Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011; 13:132-141. https://doi.org/10.1038/ncb2152 |
||||
| 14. Swati S, Sonia, Sheetal K. Effects of aerobic versus resistance training on blood pressure in hypertensive patients. J Anaesth Crit Care. 2015; 3(3):14-12. | ||||
| 15. Mayorov DN. Brain angiotensin AT 1 receptors as specific regulators of cardiovascular reactivity to acute psychoemotional stress. Clin Exp Pharmacol Physiol. 2011; 38:126-35. https://doi.org/10.1111/j.1440-1681.2010.05469.x |
||||
| 16. Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V. Regulation of Uric Acid Metabolism and Excretion. Int J Cardiol. 2016; 213:8-14. https://doi.org/10.1016/j.ijcard.2015.08.109 |
||||
| 17. Grayson PC, Kim SY, LaValley M, Choi HK. Hyperuricemia and Incident Hypertension: A Systematic Review and Meta-Analysis. Arthritis Care Res (Hoboken). 2011; 63(1):102-10. https://doi.org/10.1002/acr.20344 |
||||
| 18. Sliwa K, Stewart S, Gersh BJ. Hypertension: a global perspective. Circulation. 2011; 123:2892-96. https://doi.org/10.1161/CIRCULATIONAHA.110.992362 |
||||
| 19. Eleftheriadis T, Golphinopoulos S, Pissas G, Stefanidis I. Asymptomatic Hyperuricemia and Chronic Kidney Disease: Narrative Review of a Treatment Controversial. J Adv Res. 2017; 8(5):555-60. https://doi.org/10.1016/j.jare.2017.05.001 |
||||
| 20. Pescatello LS, Blanchard BE, Heest JLV, et al. The metabolic syndrome and the immediate antihypertensive effects of aerobic exercise: a randomized control design. BMC Cardiovasc Disord. 2008; 8:12. https://doi.org/10.1186/1471-2261-8-12 |
||||
| 21. Palmer BF, Fenves AZ. Optimizing blood pressure control in patients with chronic kidney disease. Proc (Bayl Univ Med Cent). 2010; 23:239-45. https://doi.org/10.1080/08998280.2010.11928626 |
||||
| 22. Ito D, Ito O, Cao P, Mori N, Suda C, Muroya Y, Takashima K, Ito S, Kohzuki M. Effects of exercise training on nitric oxide synthase in the kidney of spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 2013; 40:74-82. https://doi.org/10.1111/1440-1681.12040 |
||||
| 23. Hirai DM, Copp SW, Ferguson SK, Holdsworth CT, McCullough DJ, Behnke BJ, Musch TI, Poole DC. Exercise training and muscle microvascular oxygenation: functional role of nitric oxide. J Appl Physiol (1985). 2012; 113:557-65. https://doi.org/10.1152/japplphysiol.00151.2012 |
||||
| 24. Macpherson RE, Huber JS, Frendo-Cumbo S, Simpson JA, Wright DC. Adipose Tissue Insulin Action and IL-6 Signaling after Exercise in Obese Mice. Med Sci Sports Exerc. 2015; 47:2034-42. https://doi.org/10.1249/MSS.0000000000000660 |
||||
| 25. Xiong XJ, Li SJ, Zhang YQ. Massage therapy for essential hypertension: a systematic review. J Hum Hypertens. 2014; 29:143-51. https://doi.org/10.1038/jhh.2014.52 |
||||
| 26. Sriramula S, Haque M, Majid DS, Francis J. Involvement of tumor necrosis factor-alpha in angiotensin II-mediated effects on salt appetite, hypertension, and cardiac hypertrophy. Hypertension. 2008; 51:1345-51. https://doi.org/10.1161/HYPERTENSIONAHA.107.102152 |
||||
| 27. Myers J. Exercise and cardiovascular health. Circulation. 2003; 107:2e-e5. https://doi.org/10.1161/01.CIR.0000057701.80262.5C |
||||
| 28. Wen CP, Wai JP, Tsai MK, et al. Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. Lancet. 2011; 378:1244-53. https://doi.org/10.1016/S0140-6736(11)60749-6 |
||||
| 29. Mansia G, De BG, Dominiczak A, et al. 2007 ESH-ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J. 2007; 34:2159-219. https://doi.org/10.1097/HJH.0b013e3281fc975a |
||||
| 30. Nyberg M, Jensen LG, Thaning P, et al. Role of nitric oxide and prostanoids in the regulation of leg blood flow and blood pressure in humans with essential hypertension: effect of high-intensity aerobic training. J Physiol. 2012; 590(Pt 6):1481-94. https://doi.org/10.1113/jphysiol.2011.225136 |
||||
| 31. Feng RN, Zhao C, Sun CH, et al. Meta-analysis of TNF 308 G/A polymorphism and type 2 diabetes mellitus. Plos One. 2011; 6:e18480. https://doi.org/10.1371/journal.pone.0018480 |
||||
| 32. Lamina S, Okoye GC. Effects of aerobic exercise training on psychosocial status and serum uric acid in men with essential hypertension: a randomized controlled trial. Ann Med Health Sci Res. 2012; 2:161-8. https://doi.org/10.4103/2141-9248.105665 |
||||
| 33. an de Werf F, Bax J, Betriu A, Blomstrom-Lundqvist C, et al. Management of Acute Myocardial Infarction in patients presenting with ST-segment elevation. The Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J 2008; 29:2909-2945. | ||||
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