Study of the clinical significance of serum albumin level in Preeclampsia and in the detection of its severity

American Journal of BioMedicine  Volume 2, Issue 8, pages 899-902, August 2014

Basima Al Ghazali; Ahlam Abdul-Hussein Al-Taie; Raheem J. Hameed


Pre-eclampsia is a form of severe disorder of pregnancy, leading to maternal and perinatal morbidity and mortality. Many biochemical markers of preeclampsia have been recognized in maternal serum one of them is serum albumin. The objective of this study is to determine whether plasma albumin level (ALB) is associated with preeclampsia (PE) complications and to evaluate the usefulness of its level as a marker of preeclampsia severity. The studied group were collected in the labour word. First group were normotensive as a control group, the second group with a gestational hypertension, the third group were mild preeclampsia and fourth group had sever preeclampsia. A comparison of the characteristic of each group and the correlation between serum albumin levels and gestational age at time of delivery, pregnancy complications and outcome were statistically analyzed. The results are showed that serum albumin level had statistically significant decline at (P≤0.01) in severe preeclampsia with mean level (2.618-0.328) than in mild preeclampsia (3.155-0.293) in comparison to hypertensive and control group (3.500-0.386), (4.076-1.448) respectively so there is positive correlation between serum albumin levels and severity of disease. We are concluded that serum albumin level in pre-eclampsia can be used as a significant determinant of disease severity and may be used as a useful marker for predicting time of delivery or termination of pregnancy and pregnancy outcomes.

Keywords: Pregnancy; Preeclampsia; Severe preeclampsia; Serum albumin

Open Access              Full Text-PDF                Feedback


1. Duley L. Preeclampsia and hypertensive disorders of pregnancy. Br Med Bull 2003;67:161-76. [PubMed]

2. Simon J. Pregnancy complication, Oxford of obstetrics and gynecology, 2nd   Edi. ,2010;43-105.

3. Edmonds K. Hypertensive disorders, Dewhurts textbook of obstetrics and gynecology 7th edition 2007 227-236.

4. Higby K, Suiter CR, Phelps JY, Siler-Khodr T, Langer O. Normal values of urinary albumin and total albumin excretion during pregnancy. Am J Obstet Gynecol 1994;171(4):984-9. [PubMed]

5. Kieler H, Zettergren T, Svensson H, Dickman PW, Larsson A. Assessing urinary albumin execretion in pre-eclamptic women: which sample to use? BJOG. 2003;110(1):12-7. [PubMed]

6. Gojnic M, Petkovic S, Papic M, Mostic T, Jeremic K, Vilendecic Z, Djordjevic S. Plasma albumin level as an indicator of severity of preeclmpsia. Clin Exp Obstet Gynecol 2004; 31(3):209-10. [PubMed]

7. Doumas BT, Watson WA, Biggs HG. Albumin standards and measurement of serum albumin with bromocresol green. Clin Chim Acta 1971; 31(1):87-96. [PubMed]

8. Tietz NW. Clinical Guide to laboratory Test, 3rd edition (1995). 22-23.

9. Cruz MO, Gao W, Hibbard JU. Obstetric and prenatal outcome among women with gestational hypertension, mild PE  and sever PE. Am J Obstet Gynecol 2011; 205(3):260.e1-9. [PubMed]

10. Project, an enquiry into quality of care and its effect on survival of babies born at 27-28 weeks, London stationary office. 27/28: (2003).

11. Seong WJ, Chong GO, Hong DG, Lee TH, Lee YS, Cho YL, Chun SS, Park IS. Clinical significance of serum albumin level in pregnancy-related hypertension. 2J Obstet Gynaecol Res. 2010; 36(6):1165-73. [PubMed]

12. Taylor RN, Musci TJ, Kuhn RW, Roberts JM. Partial characterization of a normal growth factor from the blood of women with preeclampsia. J Clin Endocrinol Metab 1990;70(5):1285-91. [PubMed]

13. Olooto WE, Amballi AA, Mosuro AO, Adeleye AA, Banjo TA. Assessment of Total Protein, Albumin, Creatinine and Aspartate Transaminase level in Toxemia of Pregnancy. Journal of Medical Sciences 2013;13: 791-796. [Abstract/Full-Text]

14. Witlin AG, Saade GR, Mattar F, Sibai BM. Risk factors for abruption placentae and eclampsia :Analysis of 445 consecutively managed women with sever preeclampsia and eclampsia. Am J Obstet Gynecol 1999;180(6 Pt 1):1322-9. [PubMed]

Print Friendly, PDF & Email