Month: November 2014


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Endotoxemia-suppress cardiac function through dysregulation of mitochondrial biogenesis in mice model

Michele M. Bracale 1, Robyn B. Wonderge, Min Zhou, Evelyn G. Hazen*   Abstract Sepsis exaggerated proinflammatory response to infection that can progress to carries a significant cardiac dysfunction associated with morbidity and mortality. Mitochondrial biogenesis is involved in the control of cell metabolism, signal transduction, and regulation of mitochondrial reactive oxygen species (ROS) production. We are […]

Exacerbates kidney injury in mice subjected to sepsis: critical impact of used heparin

  American Journal of BioMedicine  Volume 2, Issue 11, pages1175-1187 November 2014 Peter Weighardt; Niels Hayashi; Gordon Medzhitov; Sean Newcomb Abstract Sepsis is the leading cause of death in critically ill patients, and the incidence of sepsis is increasing causes multiorgan failure, including acute kidney injury (AKI) and patients with both sepsis and AKI have […]

Role of CD70 in pathogenesis of ovarian cancer cell metastasis

  American Journal of BioMedicine  Volume 2, Issue 11, pages1160-1174 November 2014 Jack L. Pincheira; Maria Wiseman; Florian K. Dinulescu Abstract American Cancer Society identifying ovarian carcinoma as the gynecologic malignancy with the highest case-to-fatality. Ovarian carcinoma metastasizes either by direct extension from the ovarian/fallopian tumor to neighboring organs (bladder/colon) or when cancer cells detach […]