American Journal of BioMedicine Volume 2, Issue 12, pages1229-1239 December 2014 Bassim I Mohammad; Nada Al-Haris; Najah Hadi; Maitham G. Yousif; Zainab Alkefaee Abstract Doxorubicin (Dox) is one of the most potent broad-spectrum antitumor anthracycline antibiotics, but its use is limited by the development of life-threatening cardiomyopathy. This study was undertaken to investigate the […]
Month: December 2014
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Expression of ATF3 in mouse protects the liver against sepsis via inhibiting HMGB expression
Ya Yun 1, Xing Zheng, Lijuan Chen,Yong Su, Chin-Fen Kim, Mao Zhao* Abstract Lipopolysaccharides are components of Gram-negative enterobacteria that cause septic shock in mammals and triggers innate immunity mainly via TLR4 signaling. HMGB1 play a critical role in regulating innate immunity-induced sepsis. ATF3 is a negative regulator of TLR4 signaling and the mechanism […]