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Month: December 2014
Expression of ATF3 in mouse protects the liver against sepsis via inhibiting HMGB expression
Ya Yun 1, Xing Zheng, Lijuan Chen,Yong Su, Chin-Fen Kim, Mao Zhao* Abstract Lipopolysaccharides are components of Gram-negative enterobacteria that cause septic shock in mammals and triggers innate immunity mainly via TLR4 signaling. HMGB1 play a critical role in regulating innate immunity-induced sepsis. ATF3 is a negative regulator of TLR4 signaling and the mechanism […]
Suppressions of metastatic breast cancer invasion and metastasis to brain/cross talk HER2/ERK1/2/MMP-9 signaling pathway
American Journal of BioMedicine Volume 2, Issue 11, pages1197-1209 November 2014 Yu-Chun Lin ; Dong-Qing Chin; Eva Wang; Hao Cheng Abstract Understanding the molecular pathways that contribute to the development of metastatic breast cancer invasion and metastasis to brain is needed to improve the clinical utility of novel agents, and to predict the success of […]
NFATc3 is necessary for macrophage iNOS expression during myocardial ischemia and reperfusion
American Journal of BioMedicine Volume 2, Issue 11, pages1188-1196 November 2014 You-lin Lee; Qiong Chung; Lei Zhang; Zhu Shen; Jie Chan Abstract In the present study, we sought to examine whether inhibition NFATc3, improves cardiac function and reduces heart damage during IR. Hearts of male C57BL/J6 and NFATc3 knockout (KO) mice perfused by Langendorff […]