Research Article
American Journal of BioMedicine
Volume 11, Issue 1, 04 January 2023, Pages 1-9 | http://dx.doi.org/10.18081/2333-5106/2023.11/1
Martín Pérez-Vázquez 1, Psarova O. V 1, 2, Palero S *1
Received 10 September 2022 Revised 14 November 2022 Accepted 03 December 2022 Published 04 January 2023
Abstract
The objective of this study is investigating the role of excessive activation PI3K/Akt/mTORC1 in diabetes mellitus type 2. It’s known that the PI3K/Akt/mTORC1 pathway is involved in the pathogenesis of cancer. Study design was carried out in accordance with the guidelines of the Helsinki Declaration that included normal patients as control (n = 15), second group included patients with diabetes mellitus type 2 (n = 22) while, third group included patients with malignancy positive mTORC1 (n = 22). 81 women were examined and enrolled in this study with age from 40 to 75-year-old. Diabetes mellitus type 2 compensation was assessed by determining the level of HbA1c by the method of ion-exchange chromatography, using the BIO-RAD D-10 analyzer, PRAS40 was determined in units depending on the amount of protein in the blood cell lysates.
Keywords: Diabetes mellitus type 2; mTORC1; PI3K/Akt
Copyright © 2023 Palero S, et al. This article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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