C-MYC over-expression diffuse large B-cell lymphoma mimicking breast cancer metastases in young female

Research Article 
American Journal of BioMedicine Volume 4, Issue 6, pages 203-212
Received January 28, 2016; accepted May 25, 2016; published June 03, 2016

Nooshin bayat1, Amin rezaei2, Gholamhossein Alishiri1, Mahdi Safiabadi1mail of corresponding author


The development of increasingly effective therapies to diffuse large B-cell lymphoma that result cured in most of the patients (50%).  A 32-year old female presented with accidental nodular opacities on chest x-ray She was initially treated as an upper respiratory tract infection. However; due to persistent symptoms and hypoxia; a chest x-ray was done which showed diffuse bilateral . This was followed by a chest CT scan which showed numerous multiple masses throughout the lung fields bilaterally ranging in size from 5-25 mm. The nodules had classical appearance of cannon-balls seen often in secondary metastatic neoplasms to the lung. However; biopsy showed diffuse large Bcell lymphoma with a proliferation index (Ki-67) of 100% and C-MYC positivity by immunohistochemical stains. She was initially treated with R-CHOP chemotherapy then was switched to DA-EPOCH-R once the final cytogenetic and molecular report was available. Interim staging showed very good response.

Keywords: Rheumatoid arthritis; ESR; CRP; American College of Rheumatology criteria

Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.

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