MicroRNA-137 protects burn-induced myocardial depression via regulation of the Notch signaling pathway

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Justin Sambol¹, Jordi Horton¹, Hong Chen², Catalina Gonzales¹, Jack Faulkner¹*


Clinical and experimental evidence shows myocardial contractile depression develops 4-24 hrs post-burn. Although the pathogenesis responsible for burn-induced myocardial depression is not well known, the aim of study is to investigate the role of microRNA-34a (miR-34a) in myocardial injury following post-burn by targeting Notch signaling pathway. MicroRNAs (miRNAs) have emerged as novel regulators in various pathological processes, but the precise role of miRNAs in post burn-induced myocardial depression remains largely unknown, a model of burn procedure. The results showed that for the first time that MicroRNA-137 functionally regulates Notch signaling pathway to protect burn-induced myocardial injury. Therefore, dual targeting of both the MicroRNA-137 and Notch1 signaling axes may be a potential therapeutic avenue to inhibit the burn-induced myocardial injury.

Keywords: MicroRNA-137; Notch; Burn-induced myocardial depression

Copyright © 2016 by The American Society for BioMedicine and BM-Publisher, Inc.

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  1. Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A. Signalling downstream of activated mammalian Notch. Nature 1995;377:355-358. [PubMed]
  2. Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 1998;393:382-386.[PubMed]
  3. Jarriault S, Le Bail O, Hirsinger E, et al. Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol Cell Biol 1998;18:7423-7431. [PMC free article][PubMed]
  4. Lawson ND, Vogel AM, Weinstein BM. Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell 2002;3:127-136. [PubMed]
  5. Krebs LT, Xue Y, Norton CR, et al. Notch signaling is essential for vascular morphogenesis in mice.Genes Dev 2000;14:1343-1352. [PMC free article][PubMed]
  6. Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999;284:770-776. [PubMed]
  7. Alexiou P, Maragkakis M, Papadopoulos GL, Reczko M, Hatzigeorgiou AG. Lost in translation: an assessment and perspective for computational microRNA target identification. Bioinformatics 2009;25:3049-3055. [PubMed]
  8. Alvarez-Saavedra E, Horvitz HR. Many families of C. elegans microRNAs are not essential for development or viability. Current Biol 2010;20:367-373. [PMC free article][PubMed]
  9. Ameres SL, Horwich MD, Hung JH, Xu J, Ghildiyal M, Weng Z, Zamore PD. Target RNA-directed trimming and tailing of small silencing RNAs. Science 2010;328:1534-1539. [PMC free article][PubMed]
  10. Conlon RA, Reaume AG, Rossant J. Notch1 is required for the coordinate segmentation of somites. Development 1995;121:1533-1545. [PubMed
  11. Murohara T, Asahara T, Silver M, et al. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest 1998;101:2567-2578. [PMC free article][PubMed]
  12. Arroyo JD, Chevillet JR, Kroh EM, et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA 2011;108:5003-5008. [PMC free article][PubMed]
  13. Bao L, Zhou M, Wu L, Lu L, Goldowitz D, Williams RW, Cui Y. PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Res 2007;35:D51-54. [PMC free article][PubMed]



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DOI: 10.18081/2333-5106/016-12/543-552
American Journal of BioMedicine Volume 4, Issue 12, pages 543-552
Received July 13, 2016; accepted November 11, 2016; published December 16, 2016
Cited by in Scopus

How to cite this article
Sambol J, Horton J, Chen H, Gonzales C, Faulkner J. MicroRNA-137 protects burn-induced myocardial depression via regulation of the Notch signaling pathway. American Journal of BioMedicine 2016;4(12):543-552.

Article outline
1. Abstract
2. Keywords
3. Introduction
4. Method and Materials
5. Results
6. Discussion
7. Acknowledgements
8. References

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