Activity of Saponin in the parts of the medicinal plant Abutilon indicum

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In different aspects of life, plants form a vast field of uses such as furniture, ornaments, decoration, stationary, buildings and others. Among those uses of plants are the medical ones because of the vast varieties of plant types, the low cost and the wide range of safety when use them. Mallow family includes small trees diversity of different parts like herbs, shrubs and flowering plants. Considering the chemical structure, it confines huge range of compounds like vitamins, alkaloids, saponin glycosides, proteins, carbohydrates, flavonoids and others. Because the Abutilon indicum has reported to have analgesic, antioxidant, laxative, anthelmintic and diuretic properties, it was chosen to be the topic of study in this review. Of these mentioned compounds saponin comes on priority and it was extracted from different plants beside abutilon such as sugar beet, soymilk, strawberry, plum and chickpea. The defense system of plants bases on saponin as it forms the attack line against pathogens. Saponin can be found in percentage about 30% in the leaves of Abutilon indium and it is seen to have cholesterol and glucose lowering properties beside antitumor ones. The study about the pharmacological properties of A. Indicum in Iraq area was recommended by the author to establish its effects against chronic diseases depending different doses in experimental animals.
Keywords: Abutilon indicium, Saponin

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  1. Mohite MS, Shelar PA, Raje VN, Babar SJ and Sapkal RK. Review article on pharmaceutical      properties of Abutilon indicum. Asian. J. Pharm. Res. 2012;2;(4):156-60.
  2. Chopra RN, Chopra IC, Nayer SL. Glossary of Indian medicinal plants. New Delhi: CSIR,
  3. Matlwaska. Acia Poloniac Pharmaceutic - Drug Research. 2002;1956; 59:227-229.
  4. Gomaa AA, Samy MN, Desoukey SY, Kamel MS. Phytochemistry and pharmacological activities of genus Abutilon: a review (1972-2015) J. Adv. Biomed. & Pharm. Sci. 2018; 1:56-74.
  5. Abdul MM, Sarker AA, Saiful IM, Muniruddin A. Cytotoxic and antimicrobial activity of the crude extract of Abutilon indicum. International Journal of Pharmacognosy and Phytochemical Research 2010;2:1.
  6. Jelena D, Djurasevic S, Vuckovic T, Jasnic N, Gordana C. Effect of cold and heat stress on rat adrenal, serum and liver ascorpic acid concentration. Arch. Biol. Sci. Belgrade. 2006; 58(3):161-164.
  7. Kannabiran K, Mohankumar T, Gunaseker V. Evaluation of antimicrobial activity of saponin isolated from Solanum xanthocarpum and Centella asiatica. Int J Natl Eng Sci. 2009;3(1):25-8.
  8. Ncube NS, Afolayan AJ, Okoh AI. Assessment techniques of antimicrobial properties of natural compounds of plant origin: current methods and futuretrends. Afr.J. Biotechnol. 2008; 7(12): 1797-1806.
  9. Kousalya M, Kokila N, Balamurugan N. Evaluation of acute toxicity study of root of abutilon indicum [L] sweet. International Journal of frontiers in science and technology. 2014;2(3):32.
  10. Dashputre NL, Naikwade NS. Immuno modulatory activity of Abutilon indicum linn on albino mice. Int J Pharm Sci Res. 2010;1(3),178-184.
  11. Kaushik P, Kaushik D, Lal Khokra S, sharm A. Antidiabetic Activity of the Plant Abutilon indicum in Streptozotocin-Induced Experimental Diabetes in Rats. International Journal of Pharmacognosy and Phytochemical Research. 2010; 2(2); 45-49.
  12. Reddy TU, Lakshmi MS, Ashok Kumer CK, Prathyusha S, Andsateeh Kumar D. Protective effect of abutilon indicum L. (MALVACEAE) against acetaminophen induced nephrotoxicity in rats. Innovare Journal of Life Sciences 2013; 1:40-43.
  13. Singh R, Mendhulkar V. Abutilon indicum (Linn.) Sweet leaves, a natural source of saponin: A spectrophotometric assay. Int J PharmTech Res. 2015; 2(1):1-4.
  14. Johri R, Pahwa G, Sharma S, Zutshi U. Determination of estrogenic/antiestrogenic potential of antifertility substances using rat uterine peroxidase assay. Contraception1991; 44(5):549-57.
  15. Revansiddaya P, Kalyani B, Veerangouda, A, Shivkumar H. Payghan Santosh Hepatoprotective and Antioxidant Role of Flower Extract of Abutilon indicum International Journal of Pharmaceutical & Biological Archives 2011; 2(1):541-545.
  16. Mshary GS, Kadhim ZY. Evaluation of hematological and biochemical parameters of the heat-stress rats treated with Abutilon indicum aqueous extract. MRVSA 2017; 6 (3), 25-31.
  17. Hostettmann K, Marston A.  Saponins. Cambridge University Press, Cambridge 2005.
  18. Francis G, Kerem Z, Makkar HPS, Becker K. The biological action of saponins in animal systems: a review. Brit J Nutr 2002; 88:587-605.
  19. Hostettmann KA, Marston A. Saponins (Cambridge Univ. Press, Cambridge, UK 1995.
  20. Moses T, Pollier J, Thevelein JM, Goossens A. Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro. New Phytol 2013; 200:27 43.
  21. Sparg SG, Light ME, van Staden J. Biological activities and distribution of plant saponins. J Ethnopharmaco 2004; 94:219-243.
  22. Van Dyck S, Flammang P, Meriaux C, et al. Localization of secondary metabolites in marine invertebrates: contribution of MALDI MSI for the study of saponins in cuvierian tubules of H. forskali. PLoS. One.2010;5: e13923.
  23. Tang HF, Cheng G, Wu J, et al. Cytotoxic astero saponins capable of promoting polymerization of tubulin from the starfish Culcita novaeguineae. J Nat Prod 2009; 72:284-289.
  24. Khadabadi SS, Bhajipale NS. Review on some important medicinal plants of Abutilon species. Res J Pharm Biol Chem Sci 2010;1(4):718-29.
  25. Shrikanth VM, Janardhan B, More S, Muddapur U, Mirajkar K. In vitro anti snake venom potential of Abutilon indicum Linn leaf extracts against Echis carinatus (Indian saw scaled viper). JPP 2014; 3 (1): 111-117.
  26. Kumar RS, Danie JA, Jeyachristy SA, Devi SA. Hepatoprotective Role of Abutilon indicum on Lead Induced Liver Injury in Wistar Rats 2016.
  27. Sharma SK, Sharma SM, Saini V, Mohapatra S. Evaluation of anti-ulcerogenic potential of Abutilon Indicum. International Research Journal of Pharmacy 2013; 4(3):233-6.
  28. Bhajipale NS. Evaluation of anti-arthritic activity of methanolic extract of Abutilon indicum.International Journal of Ayurvedic and Herbal Medicine 2012; 2(03):598-603.
  29. Rajalakshmi P, Vairavasundaram,  Kalaiselvi S. Drug Invention Today 2009;1(2):137-139.
  30. Porchezhian E, Ansari SH. Hepatoprotective activity of A. indicum on experimental liver damage in Rats. Phytomedicine 2005;12: 62-64.
  31. Singh R, Mendhulkar VD. Abutilon indicum (Linn.) Sweet leaves, a Natural source of Saponin : a Specrtophotometric assay CODEN (USA): IJPRIF 2015;8:725-729.
  32. Vig M, Bhati J. Antimicrobial potential of Abutilon indicum extract.  Int. Res. J. Pharm. 8 (9) International research journal of pharmacy. irjponlin  2017.
  33. Singh D, Singh VS. Phytochemical Analysis and Antimicrobial Activity of
  34. Chloroform Extract of Abutilon indicum 2016.
  35. Thooyavan G, Karthikeyan J, Govindarajalu B. Anthelmintic activity of abutilon indicum leaf extract on sheep tapeworm Moniezia expansa In vitro JPP 2018; 7(2): 317-32.
  36. Tas S, Sarandol E, Ziyanok-Ayvalik S, Ocak N, Serdar Z, Vanadyl DM. Sulfate treatment improves oxidative stress and increases serum paraoxonase activity in streptozotocin-induced diabetic rats. Nutr Res 2006; 26:670-6.
  37. Dharmesh GK, Laxman PD, Santosh VK, Sunil B, Munesh M, Piyush P. International Journal of Pharmacy and Pharmaceutical Sciences. 2010; 2(1):66-71.
  38. Kumar VP, Chauhan NS, Padh H, Rajani M.  Search for antibacterial and antifungal agents from selected Indian medicinal plants. J Ethnopharmacol. 2006;107:182.
  39. Rajakaruna N, Cory S, Harris, Towers GHN. Antimicrobial activity ofplants collected from Serpentine outcrops in Sri Lanka,Pharmaceutical Biology 2002; 40:235-244.
  40. Sharma PV, Ahmed ZA. Phytochemistry 1989;28(12),3525.
  41. Yaldiz1 G, Yildirim1 AB, Yeliz K. yield features, phytochemical composition, antioxidant and antibacterial activities of Abutilon indicum cultivated under different fertilizers 2016.
  42. Thongsiri P. Anti-diabetic activity of Thai medicinal herbs in normal and streptozotocin-diabetic rats (M.S. thesis). Nakorn Pathom: Faculty of Graduate studies, Mahidol University, Thailand 2001.
  43. Thanigaiarassu RR, Kannabiran K, Gopieshkhanna V. Antibacterial activity of saponin isolated from the leaves of Solanum trilobatum Linn. J Appl Biol Sci.2008;2(3):109-12.
  44. Suresha PG, Ganesana R, Dharmalingama M, Baskara SP, kumarb S. Evaluation of Wound Healing Activity of "Sbutilon Indicum" Linn, In Wister Albino RatsInt J Biol Med Res.2011; 2(4): 908 - 911.
  45. Matsuura M. Saponins in garlic as modifiers of the risk of cardiovascular disease. J. Nutr 2001;131:1000-1005.
  46. Cheeke PR. Actual and potential applications of Yucca schidigera and Quillaja saponaria saponins in human and animal nutrition. Proc Am Soc Anim Sci.2000; 77:1-10.
  47. Lilian UT. Potential health benefits and problems associated with antinutrients in foods. Food Res Int.1993;26(2):131-49.
  48. Ridout CL, Price KR, DuPont MS, Parker ML, Fenwick GR. Quinoa saponins-Analysis and preliminary investigations into the effects of reduction by processing. J Sci Food Agric.1991;54:165-76
  49. Gurfinkel DM, Rao AV. Soyasaponins: the relationship between chemical structure and colon anticarcinogenic activity. Nutr Cancer 2003;47:24-33.
  50. Sodipo OA, Akanji MA, Kolawole FB, Adutuga OO. Saponin is the active antifungal principle in Garcinia kola, heckle seed, Biosci. Res.Comm 1991;3: 171.
  51. Mayank Thakur Matthias F Melzig Hendrik Fuchs Alexander Weng. Chemistry and pharmacology of saponins: special focus on cytotoxic properties Botanics: Targets and Therapy 2011.
  52. Baumann E, Stoya G, Völkner A, Richter W, Lemke C, Linss W. Hemolysis of human erythrocytes with saponin affects the membrane structure. Acta Histochem 2000;102(1):21-35.
  53. Khalil AH, El-Adawy TA. Isolation, identification and toxicity of saponin from different legumes. Food Chemistry 1994; 50:197-201.
  54. Wang Y, Zhang Y, Zhub Z, et al. Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins. Bioorganic & Medicinal Chemistry 2007;15: 2528-2532.
  55. ElAziz MMA, Ashour AS, Melad ASG. A review on saponins from medicinal plants: chemistry, isolation, and determination.J Nanomed Res 2019;8(1):6-12.
  56. Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and extraction: a review. International pharmaceutica  asciencia. 2011;1(1): 98-106.
  57. Netala VR, Ghosh SB, Bobbu P, Anitha D, Tartte V. Triterpenoid saponins: A review on biosynthesis,applications and mechanism of their action. Int. J. Pharm. Pharm. Sci 2014; 7:24-28.
  58. Cox JC, Coulter AR, Morein B, Lovgren-Bengtsson K, Sundquist B. Saponin preparations and use thereof in ISCOMS. US Patent 2002;6;352,697.
  59. Milgate J, Roberts D. The nutritional & biological significance of saponins. Nutr. Res1995;15, 1223-1249.
  60. Köse MD, Bayraktar O. Extraction of Saponins from Soapnut (Sapindus Mukorossi) and Their Antimicrobial Properties. World Journal of Research and Review (WJRR). 2016;2(5):89-93.x

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Research Article
American Journal of BioMedicine Volume 9, Issue 1, pages 55-61
Received October 13, 2020; Accepted December 22, 2020; Published February 28, 2021

How to cite this article
Mshary GS, Khudhur HB, Al-Yasari A. Activity of Saponin in the parts of the medicinal plant Abutilon indicum. American Journal of BioMedicine 2021;9(1):55-61.
Research Article
1. Abstract
2. Keywords
3. Introduction
4. Methods
5. Results
6. Discussion
7. References

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