Abnormal thyroid function and risk factor of gestational diabetes mellitus: a systematic review and meta-analysis

AJBM crossMark

Downloads: 118
El Houssaine Mansour, Omar Bouamra ¹*
Author Affiliations
¹∗Casablanca, Morocco

Abstract

Thyroid autoimmunity is a common disorder in women of reproductive age. Previous studies have shown that thyroid disorders or abnormal thyroid function test results during pregnancy might act as a risk factor for gestational diabetes mellitus. The objective this study is  to identify the association between thyroid autoimmunity and subclinical hypothyroidism as risk factors for gestational diabetes mellitus. We conducted a comprehensive literature review and meta-analysis through searching the online MEDLINE and EMBASE databases. Studies were selected according to the inclusion criteria and were subsequently subjected to a meta-analysis. Cochran's Q test was performed, and heterogeneity was assessed using the I2 index. Publication bias of the studies in the meta-analysis was investigated using Egger's method. Subgroup analysis was conducted to assess heterogeneity. The results showed that the total, 1023 citations were screened, with 14 studies included in our meta-analysis. The pooled OR for GDM was 1.50 [1.07-2.09] in positive TPOAb+/high TSH pregnancies compared with controls, the pooled OR was 1.45 [1.05-1.99] in subclinical hypothyroidism pregnancies, and the pooled OR was 1.82 [1.27-2.61] in positive TPOAb pregnancies. Pregnant women with positive TPOAb+/high TSH and those with subclinical hypothyroidism tend to have a higher risk of developing gestational diabetes mellitus. Thyroid autoimmunity and subclinical hypothyroidism should be carefully monitored in pregnant women because of the possible increased risk of gestational diabetes mellitus.

Keywords: Diabetes mellitus; Gestation; Pregnant women

Copyright © 2019 by The American Society for BioMedicine and BM-Publisher, Inc.

Article citationReferencesFeedback
The citation data is computed by the following citation measuring services:

Google scholarcitedby

  1. Farouqi A, Harti M, Nejjari C. Prise en charge du diabète au Maroc: résultats de l’International Diabetes Management Practices Study (IDMPS) – Vague 2 [Management of diabetes in Morocco: Results of the International Diabetes Management Practices Study (IDMPS) – Wave 2]. Med Mal Metab 2010;4:704-711. [Google Scholar]
  2. Gagliardino J, Aschner P, Baik S, Chan J, Chantelot J, Ilkova H. Patients’ education, and its impact on care outcomes, resource consumption and working conditions: data from the International Diabetes Management Practices Study (IDMPS). Diabetes Metab 2010;38:128-134. [Google Scholar]
  3. Benshalom-Tirosh D, Novack N, Press F, et al. Hypothyroidism and diabetes mellitus-a risky dual gestational endocrinopathy. Peer J 2013;1:e52. [Crossref] [PubMed] [Scopus (5)]
  4. Sahu MT, Das V, Mittal S, Agarwal A, Sahu M. Overt and subclinical thyroid dysfunction among Indian pregnant women and its effect on maternal and fetal outcome. Arch Gynecol Obstet 2010;281:215-220. [Crossref] [PubMed] [Scopus (71)]
  5. Tudela CM, Casey BM, McIntire DD, Cunningham FG. Relationship of subclinical thyroid disease to the incidence of gestational diabetes. Obstet Gynecol 2012;119:983-988. [Crossref] [PubMed] [Scopus (40)]
  6. Yang WS, Va P, Bray F, et al. The role of pre-existing diabetes mellitus on hepatocellular carcinoma occurrence and prognosis: a meta-analysis of prospective cohort studies. PLoS ONE 2011;6:e27326. [View Article] [PubMed/NCBI]
  7. Inoue M, Iwasaki M, Otani T, et al. Diabetes mellitus and the risk of cancer. Arch Intern Med 2006;166:1871-1877. [View Article] [PubMed/NCBI] [Google Scholar]
  8. Dvey-Smith G, Egger M, Shipley MJ, Marmot M. Post-challenge glucose concentration, impaired glucose tolerance, diabetes, and cancer mortality in men. Am J Epidemiol 1991;136:1110-1114. [PubMed/NCBI]
  9. Widerpass E, Gridley G, Nyren O, et al. Cause-specific mortality in a cohort of patients with diabetes mellitus: a population-based study in Sweden. J Clin Epidemiol 2001;54:802-809. [PubMed]
  10. Meinhold CL, Ron E, Schonfeld SJ, et al. Nonradiation Risk Factors for Thyroid Cancer in the US Radiologic Technologists Study. American Journal of Epidemiology 2009;171:242-252. [PubMed]
  11. Chubb, SAP, Davist, WA, Inman, Z, Davis, TME. Prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes: the fremantle diabetes study. Clinical Endocrinology. 2005;62(4):480-486. [PubMed]
  12. Barker JM. Clinical review: type 1 diabetes-associated autoimmunity: natural history, genetic association and screening. Journal of Clinical Endocrinology and Metabolism 2006;91(4):377-386.
  13. Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. The Lancet 2009;373(9677):1773-1779.
  14. Chubb SA, Davis WA, Davis TM. Interactions among thyroid function, insulin sensitivity and serum lipid concentration: the Freemantle diabetes study. Journal of Clinical Endocrinology and Metabolism 2005;90(9):2317-2320.
  15. Landon MB, Spong CY, Thom E, et al. A multicenter, randomized trial of treatment for mild gestational diabetes. N Engl J Med 2009;361:1339-1348. [PMC free article] [PubMed]
  16. Langer O, Anyaegbunam A, Brustman L, Divon M. Management of women with one abnormal oral glucose tolerance test value reduces adverse outcome in pregnancy. Am J Obstet Gynecol 1989;161:593-599. [PubMed]
  17. Li DF, Wong VC, O'Hoy KM, Yeung CY, Ma HK. Is treatment needed for mild impairment of glucose tolerance in pregnancy? A randomized controlled trial. Br J Obstet Gynaecol 1987;94:851-854. [PubMed]
  18. Agarwal MM, Dhatt GS, Punnose J, Koster G. Gestational diabetes: dilemma caused by multiple international diagnostic criteria. Diabet Med 2005;22:1731-1736. [PubMed]
  19. Simmons R. Epigenetics and maternal nutrition: nature v. nurture. Proc Nutr Soc 2011;70:73-81. [PubMed]
  20. Forman MR CM, Ronckers C, Zhang Y. Through the looking glass at early-life exposures and breast cancer risk. Cancer Invest 23:609-624. [PubMed]
  21. Langer O, Levy J, Brustman L, et al. Glycemic control in gestational diabetes mellitus—how tight is tight enough: small for gestational age versus large for gestational age? Am J Obstet Gynecol 1989;161:646-653. [PubMed]
  22. Sadeh-Mestechkin D, Walfisch A, Shachar R, et al. Suspected macrosomia? Better not tell. Arch Gynecol Obstet 2008;278:225-230. [PubMed]
  23. Barton JR, O'Brien J M, Bergauer NK, Jacques DL, Sibai BM. Mild gestational hypertension remote from term: progression and outcome. Am J Obstet Gynecol 2001;184:979-983. [PubMed]

 

Who Can Become a Reviewer?
Any expert in the article's research field can become a reviewer with American Journal of Biomedicine. Editors might ask you to look at a specific aspect of an article,...

Find out more

Thank you for visiting American Journal of BioMedicine. * = Required fields

Error: Contact form not found.

Topic Review


DOI: http://dx.doi.org/10.18081/2333-5106/017-2/86-98
American Journal of BioMedicine Volume 7, Issue 2, pages 79-89
Received December 09, 2018; Accepted April 04, 2019; Published May10, 2019

How to cite this article
El Houssaine M, Bouamra O. Abnormal thyroid function and risk factor of gestational diabetes mellitus: a systematic review and meta-analysis. American Journal of BioMedicine 2019;7(2):79-89.

Article outline
1. Abstract
2. Keywords
3. Introduction
4. Methods
5. Results
6. Discussion
7. Acknowledgements
8. References