Sepsis-attenuated myocardial function: pathogenesis of injury with neutrophil recruitment crosstalk

Research Article

American Journal of BioMedicine
Volume 11, Issue 2,  Pages 65-75 |

Hussain Sarfaraz*, Basmah Imran, Sharaf Abidi 1 

Received  30 January  2023   Revised  18 March 2023   Accepted  11 April 2023   Published  02 May 2023


Acute myocardial injury may be induced by different causes, including myocardial ischemia-reperfusion injury, and sepsis, which represent the most common reasons for cardiac injury in hospitalized patients. Sepsis-induced myocardial injury is considered not to be associated with leukocyte infiltration into the myocytes but is shared with many crosstalk pathogeneses. In this experimental animal study, polymicrobial sepsis-induced was via cecal ligation and puncture model (CLP), in C57BL/6 male mice (25–30 g). By using neutrophil knockout mice, in which neutrophil recruitment is impaired, we analyzed the specific contribution to the pathogenesis of CLP-induced attenuated myocardial function. We investigated the degree of myocardial injury evaluated by plasma troponin, echocardiography, and histological analyses. The pathogenesis of CLP-induced myocardial injury relies on circulating inflammatory mediators. In conclusion, these resulting data explained that myocardial injury pathogenesis may help in the treatments for myocardial injury patients.

Keywords: Myocardial injury; CLP; Neutrophil recruitment; Sepsis

Copyright: © 2023 Sarfaraz et al. This article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sarfaraz H, Imran B, Abidi S. Sepsis-attenuated myocardial function: pathogenesis of injury with neutrophil recruitment crosstalk. American Journal of BioMedicine 2023; 11(2):65-75.

Chandra, S., and Vijayakumar, V. (2023). Laparoscopic ovarian electrocauterization in polycystic ovarian syndrome: outcome and Influencing factors. American Journal of BioMedicine, 11(1), 10-21.doi: 10.18081/2333-5106/2023.11/10
Sambit Chandra; Sujeet D. Vijayakumar. “Laparoscopic ovarian electrocauterization in polycystic ovarian syndrome: outcome and Influencing factors”. American Journal of BioMedicine, 11, 1, 2023, 10-21. doi: 10.18081/2333-5106/2023.11/10
Chandra, S., Vijayakumar, V. (2023). Laparoscopic ovarian electrocauterization in polycystic ovarian syndrome: outcome and Influencing factors. American Journal of BioMedicine, 11(1), PP. 10-21.doi: 10.18081/2333-5106/2023.11/10
Chandra, S., Vijayakumar, V. Laparoscopic ovarian electrocauterization in polycystic ovarian syndrome: outcome and Influencing factors. American Journal of BioMedicine, 2023; 11(1):10-21.doi: 10.18081/2333-5106/2023.11/10

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