Sepsis-attenuated myocardial function: pathogenesis of injury with neutrophil recruitment crosstalk

Research Article

American Journal of BioMedicine
Volume 11, Issue 2, Pages 65-75 | http://dx.doi.org/10.18081/2333-5106/2023.11/65

Hussain Sarfaraz*, Basmah Imran, Sharaf Abidi ¹

*Correspondence author e-mail: sarfaraz213@yahoo.com: ¹ Epidemiology and Public Health, Department of Clinical Sciences, Lahore, Pakistan..

Received 30 January 2023 Revised 18 March 2023 Accepted 11 April 2023 Published 02 May 2023

Abstract

Acute myocardial injury may be induced by different causes, including myocardial ischemia-reperfusion injury, and sepsis, which represent the most common reasons for cardiac injury in hospitalized patients. Sepsis-induced myocardial injury is considered not to be associated with leukocyte infiltration into the myocytes but is shared with many crosstalk pathogeneses. In this experimental animal study, polymicrobial sepsis-induced was via cecal ligation and puncture model (CLP), in C57BL/6 male mice (25–30 g). By using neutrophil knockout mice, in which neutrophil recruitment is impaired, we analyzed the specific contribution to the pathogenesis of CLP-induced attenuated myocardial function. We investigated the degree of myocardial injury evaluated by plasma troponin, echocardiography, and histological analyses. The pathogenesis of CLP-induced myocardial injury relies on circulating inflammatory mediators. In conclusion, these resulting data explained that myocardial injury pathogenesis may help in the treatments for myocardial injury patients.

Keywords: Myocardial injury; CLP; Neutrophil recruitment; Sepsis

Copyright: © 2023 Sarfaraz et al. This article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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APA

Chandra, S., and Vijayakumar, V. (2023). Laparoscopic ovarian electrocauterization in polycystic ovarian syndrome: outcome and Influencing factors. American Journal of BioMedicine, 11(1), 10-21.doi: 10.18081/2333-5106/2023.11/10

MLA

Sambit Chandra; Sujeet D. Vijayakumar. “Laparoscopic ovarian electrocauterization in polycystic ovarian syndrome: outcome and Influencing factors”. American Journal of BioMedicine, 11, 1, 2023, 10-21. doi: 10.18081/2333-5106/2023.11/10

HARVARD

Chandra, S., Vijayakumar, V. (2023). Laparoscopic ovarian electrocauterization in polycystic ovarian syndrome: outcome and Influencing factors. American Journal of BioMedicine, 11(1), PP. 10-21.doi: 10.18081/2333-5106/2023.11/10

VANCOUVER

Chandra, S., Vijayakumar, V. Laparoscopic ovarian electrocauterization in polycystic ovarian syndrome: outcome and Influencing factors. American Journal of BioMedicine, 2023; 11(1):10-21.doi: 10.18081/2333-5106/2023.11/10